Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 7/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18406930 | 0.93 | CTSL (0.45) | CTSLCTSSHCAR2PIN1AKR1B10 | |
| SCHEMBL18406913 | 0.93 | CTSL (0.45) | CTSLCTSSHCAR2PIN1AKR1B10 | |
| SCHEMBL18405721 | 0.90 | CTSL (0.43) | CTSLCTSSHCAR2PIN1ALDH1A1 | |
| SCHEMBL18406922 | 0.80 | CTSL (0.47) | CTSLCTSSHCAR2PIN1CYP3A4 | |
| SCHEMBL18406929 | 0.80 | CTSL (0.47) | CTSLCTSSHCAR2PIN1CYP3A4 | |
| SCHEMBL18406924 | 0.80 | CTSL (0.43) | CTSLCTSSHCAR2PIN1ALDH1A1 | |
| SCHEMBL18406918 | 0.80 | CTSL (0.43) | CTSLCTSSHCAR2PIN1ALDH1A1 | |
| SCHEMBL18411617 | 0.79 | CTSL (0.38) | CTSLCTSSHCAR2PIN1ALDH1A1 | |
| SCHEMBL18406919 | 0.79 | CTSL (0.46) | CTSLCTSSHCAR2PIN1POLB | |
| SCHEMBL18406928 | 0.79 | CTSL (0.46) | CTSLCTSSHCAR2PIN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170022153-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | Nguyen, Mark Quang (US) | 2017-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022153-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | FH, FPGS, APC | CTSL 2900/4885CTSS 1115/4885HCAR2 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.