Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365231 | 0.92 | GRM5 (0.37) | GRM5CNR2AVPR1BCXCR3MEN1 | |
| SCHEMBL19706090 | 0.89 | GPR52 (0.35) | TRPV3KIF18AMAPTRAF1SMN1; SMN2 | |
| SCHEMBL12654415 | 0.87 | GRM5 (0.34) | GRM5CNR2TRPV3AVPR1BKIF18A | |
| SCHEMBL17655390 | 0.84 | GRM5 (0.47) | GRM5CNR2MAPTKMT2ACNR1 | |
| SCHEMBL19865037 | 0.83 | GRM5 (0.36) | GRM5CNR2AVPR1BMEN1MAPT | |
| SCHEMBL18415690 | 0.83 | GRM5 (0.34) | GRM5CNR2TRPV3AVPR1BKIF18A | |
| SCHEMBL12654669 | 0.83 | CNR2 (0.50) | GRM5CNR2KMT2ACNR1TP53 | |
| SCHEMBL19365868 | 0.81 | GPR52 (0.38) | TRPV3KIF18AMAPTRAF1SMN1; SMN2 | |
| SCHEMBL12654526 | 0.80 | MPL (0.42) | GRM5CNR2AVPR1BCNR1TP53 | |
| SCHEMBL12654429 | 0.80 | PHGDH (0.41) | GRM5CNR2MEN1KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |