Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 6/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4933216 | 0.96 | MRGPRX4 (0.63) | MEN1KMT2AMRGPRX4MAOBALOX5 | |
| SCHEMBL4852115 | 0.91 | MAOB (0.67) | MEN1KMT2AMRGPRX4MAOBALOX5 | |
| SCHEMBL4674930 | 0.89 | MEN1 (0.70) | MEN1KMT2AMAOBALOX5CYP1A2 | |
| SCHEMBL29142397 | 0.89 | CYP1A2 (0.58) | MEN1KMT2AMRGPRX4MAOBALOX5 | |
| SCHEMBL347904 | 0.87 | MAOB (0.62) | MEN1KMT2AMRGPRX4MAOBALOX5 | |
| SCHEMBL15903046 | 0.87 | MAOB (0.62) | MEN1KMT2AMRGPRX4MAOBALOX5 | |
| SCHEMBL30884548 | 0.87 | MRGPRX4 (0.55) | MEN1KMT2AMRGPRX4MAOBALOX5 | |
| SCHEMBL7316282 | 0.86 | MRGPRX4 (0.54) | MEN1KMT2AMRGPRX4MAOBALOX5 | |
| SCHEMBL15907337 | 0.84 | MRGPRX4 (0.49) | MEN1KMT2AMRGPRX4MAOBALOX5 | |
| SCHEMBL3823697 | 0.84 | RXRA (0.69) | MAOBALOX5CYP1A2CYP2C19MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984324-B1 | MANDELIC HYDRAZIDES | MERCK PATENT GMBH (DE) | 2011-05-18 | — | — | EP | disclosed |
| US-7776920-B2 | Mandelic hydrazides | MERCK PATENT GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-7776920-B2 | Mandelic hydrazides | MERCK PATENT GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-20090221712-A1 | MANDELIC HYDRAZIDES | MERCK PATENT GESELLSCHAFT (DE) | 2009-09-03 | — | — | US | disclosed |
| US-20090221712-A1 | MANDELIC HYDRAZIDES | MERCK PATENT GESELLSCHAFT (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-1984324-A1 | MANDELIC HYDRAZIDES | Merck Patent GmbH (DE) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007093264-A1 | MANDELIC HYDRAZIDES | MERCK PATENT GMBH (DE) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221712-A1 | MANDELIC HYDRAZIDES | HK1, GLS, AGK | MEN1 2368/4885KMT2A 1864/4885MRGPRX4 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.