Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | P4HB | P07237 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031420 | 0.80 | ALDH1A1 (0.35) | MAPTKMT2AMEN1ALDH1A1ALOX15 | |
| SCHEMBL17577745 | 0.77 | ACHE (0.37) | KMT2AMEN1ALDH1A1LMNAPARP1 | |
| SCHEMBL28929035 | 0.77 | PIM1 (0.38) | ALDH1A1MAPK1CA1CA2CA7 | |
| SCHEMBL29575376 | 0.75 | PGAM1 (0.37) | STAT3 | |
| SCHEMBL9773689 | 0.75 | PGAM1 (0.37) | STAT3 | |
| SCHEMBL18368348 | 0.74 | DPP4 (0.37) | KMT2AHPGDCYP3A4BLMTSHR | |
| SCHEMBL23529900 | 0.72 | PTPRC (0.60) | MAPTKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL13930824 | 0.72 | ALDH1A1 (0.32) | ALDH1A1KDM4ESMN1; SMN2HSD11B1 | |
| SCHEMBL30489886 | 0.72 | — | — | |
| SCHEMBL28965167 | 0.72 | CA12 (0.42) | MAPTKMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118184516-A | Preparation method of N1, N5-disubstituted-1, 5-naphthalene diamine compound | 台州学院 | 2024-06-14 | — | — | CN | disclosed |
| EP-2321266-A2 | SUBSTITUTED AMINOTETRALINES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010018109-A2 | SUBSTITUTED AMINOTETRALINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-02-18 | — | — | WO | disclosed |