Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Xylitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adonitol SCHEMBL27608468 | 1.00 | TDP1 (0.67) | TDP1LMNAL3MBTL1KDM4EPDE4A | |
| Mannitol SCHEMBL21327681 | 0.93 | LMNA (0.73) | TDP1LMNAL3MBTL1KDM4EPDE4A | |
| Sorbitol SCHEMBL1605233 | 0.93 | LMNA (0.73) | TDP1LMNAL3MBTL1KDM4EPDE4A | |
| Mannitol SCHEMBL5050555 | 0.93 | LMNA (0.73) | TDP1LMNAL3MBTL1KDM4EPDE4A | |
| Adonitol SCHEMBL28031758 | 0.86 | LMNA (0.71) | TDP1LMNAL3MBTL1KDM4EPDE4A | |
| E968 SCHEMBL18493349 | 0.86 | TDP1 (0.77) | TDP1LMNAL3MBTL1KDM4EPDE4A | |
| Xylitol SCHEMBL6240620 | 0.86 | LMNA (0.71) | TDP1LMNAL3MBTL1KDM4EPDE4A | |
| Xylitol SCHEMBL4599492 | 0.86 | LMNA (0.83) | TDP1LMNAL3MBTL1KDM4EPDE4A | |
| Xylitol SCHEMBL5273838 | 0.86 | LMNA (0.83) | TDP1LMNAL3MBTL1KDM4EPDE4A | |
| Xylitol SCHEMBL8749454 | 0.86 | LMNA (0.83) | TDP1LMNAL3MBTL1KDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3132789-B1 | COSMETIC | DOW TORAY CO LTD (JP) | 2024-01-17 | — | — | EP | disclosed |
| US-10130579-B2 | Cosmetic material | DOW CORNING TORAY CO., LTD. (JP) | 2018-11-20 | — | — | US | disclosed |
| EP-3132789-A1 | COSMETIC | Dow Corning Toray Co., Ltd. (JP) | 2017-02-22 | — | — | EP | disclosed |
| US-20170035681-A1 | COSMETIC MATERIAL | DOW TORAY CO., LTD. (JP) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10130579-B2 | Cosmetic material | CUTA, H1-0, TRPA1 | TDP1 4105/4885LMNA 983/4885L3MBTL1 2330/4885 |
| US-20170035681-A1 | COSMETIC MATERIAL | CUTA, H1-0, TRPA1 | TDP1 4105/4885LMNA 983/4885L3MBTL1 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.