SCHEMBL18430442

SCHEMBL18430442

COC(=O)c1csc(-c2ccccn2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.48
▸ POLB P06746 2/20 0.48
▸ MAPT P10636 2/20 0.48
▸ TGFBR1 P36897 1/20 0.46
▸ TSHR P16473 2/20 0.46
▸ KDM6B O15054 1/20 0.46
▸ KDM5C P41229 1/20 0.46
▸ KDM4C Q9H3R0 1/20 0.46
▸ KDM2A Q9Y2K7 1/20 0.46
▸ KDM3A Q9Y4C1 1/20 0.46
▸ PKM P14618 1/20 0.45
▸ GRM5 P41594 1/20 0.45
▸ ADORA3 P0DMS8 3/20 0.44
▸ HDAC3 O15379 1/20 0.44
▸ HDAC4 P56524 1/20 0.44
▸ HDAC1 Q13547 1/20 0.44
▸ HDAC7 Q8WUI4 1/20 0.44
▸ HDAC2 Q92769 1/20 0.44
▸ HDAC10 Q969S8 1/20 0.44
▸ HDAC11 Q96DB2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27605065 0.83 KDM4E (0.49) KDM4EPOLBMAPTKDM6BKDM5C
SCHEMBL18499653 0.82 ALDH1A1 (0.42) KDM4EPOLBMAPTTSHRKDM6B
SCHEMBL29473506 0.78 CA1 (0.48) KDM4EPOLBMAPTTSHRALOX15
SCHEMBL2454052 0.77 TSHR (0.53) KDM4EPOLBMAPTTSHRRAB9A
SCHEMBL475480 0.76 AXL (0.56) KDM4EPOLBMAPTTGFBR1TSHR
SCHEMBL31463175 0.76 KDM4E (0.71) KDM4EPOLBMAPTTGFBR1TSHR
SCHEMBL7033789 0.76 KDM4E (0.71) KDM4EPOLBMAPTTGFBR1TSHR
SCHEMBL15173149 0.76 KDM4E (0.56) KDM4EPOLBMAPTTGFBR1TSHR
SCHEMBL989567 0.76 AXL (0.56) KDM4EPOLBMAPTTGFBR1TSHR
SCHEMBL5562975 0.76 GRM5 (0.64) KDM4ETGFBR1TSHRKDM6BKDM5C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10655091-B2 Thiophene azo dyes and laundry care compositions containing the same THE PROCTER & GAMBLE COMPANY (US) 2020-05-19 — — US disclosed
US-20190345415-A1 THIOPHENE AZO DYES AND LAUNDRY CARE COMPOSITIONS CONTAINING THE SAME PROCTER & GAMBLE (US) 2019-11-14 — — US disclosed
US-10435651-B2 Thiophene azo dyes and laundry care compositions containing the same THE PROCTER & GAMBLE COMPANY (US) 2019-10-08 — — US disclosed
US-20180066215-A1 THIOPHENE AZO DYES AND LAUNDRY CARE COMPOSITIONS CONTAINING THE SAME PROCTER & GAMBLE (US) 2018-03-08 — — US disclosed
US-9752104-B2 Thiophene AZO carboxylate dyes and laundry care compositions containing the same THE PROCTER & GAMBLE COMPANY (US) 2017-09-05 — — US disclosed
US-9567465-B2 Thiophene azo carboxylate dyes and laundry care compositions containing the same MILLIKEN & COMPANY (US) 2017-02-14 — — US disclosed
US-9556337-B2 Thiophene azo dyes and laundry care compositions containing the same MILLIKEN & COMPANY (US) 2017-01-31 — — US disclosed
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