Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10034110 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1MAPT | |
| SCHEMBL24018507 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1MAPT | |
| SCHEMBL18436130 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1MAPT | |
| SCHEMBL15743968 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1MAPT | |
| SCHEMBL31182223 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1MAPT | |
| SCHEMBL20456804 | 0.80 | KMT2A (0.51) | KMT2AAOC3KDM4EALDH1A1MAPT | |
| SCHEMBL17803130 | 0.80 | KMT2A (0.51) | KMT2AAOC3KDM4EALDH1A1MAPT | |
| SCHEMBL18307179 | 0.80 | KMT2A (0.51) | KMT2AAOC3KDM4EALDH1A1MAPT | |
| SCHEMBL20004006 | 0.80 | KMT2A (0.51) | KMT2AAOC3KDM4EALDH1A1MAPT | |
| SCHEMBL23019809 | 0.80 | KMT2A (0.51) | KMT2AAOC3KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |