Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20456804 | 1.00 | KMT2A (0.51) | KMT2AAOC3KDM4EALDH1A1GAA | |
| SCHEMBL10034110 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1GAA | |
| SCHEMBL18436130 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1GAA | |
| SCHEMBL31182223 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1GAA | |
| SCHEMBL15743968 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1GAA | |
| SCHEMBL24018507 | 0.81 | KMT2A (0.53) | KMT2AAOC3KDM4EALDH1A1GAA | |
| SCHEMBL20456715 | 0.80 | MAP3K12 (0.38) | MAP3K12PIK3CAMTOR | |
| SCHEMBL18436755 | 0.80 | KMT2A (0.51) | KMT2AAOC3KDM4EALDH1A1GAA | |
| SCHEMBL22837868 | 0.80 | SORD (0.35) | MAPT | |
| SCHEMBL1080321 | 0.80 | KMT2A (0.51) | KMT2AAOC3KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265607-B1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS INC (US) | 2016-12-14 | — | — | EP | disclosed |