SCHEMBL24018507

SCHEMBL24018507

Cc1ccc(N2CC(C)O[C@H](C)C2)nc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.53
AOC3 Q16853 3/20 0.52
ALDH1A1 P00352 4/20 0.46
GAA P10253 2/20 0.46
KDM4E B2RXH2 2/20 0.46
GRIN2D O15399 1/20 0.45
GRIN3B O60391 1/20 0.45
GRIN1 Q05586 1/20 0.45
GRIN2A Q12879 1/20 0.45
GRIN2B Q13224 1/20 0.45
GRIN2C Q14957 1/20 0.45
GRIN3A Q8TCU5 1/20 0.45
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
LMNA P02545 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
TLR9 Q9NR96 1/20 0.43
TLR8 Q9NR97 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15743968 1.00 KMT2A (0.53) KMT2AAOC3ALDH1A1GAAKDM4E
SCHEMBL10034110 1.00 KMT2A (0.53) KMT2AAOC3ALDH1A1GAAKDM4E
SCHEMBL18436130 1.00 KMT2A (0.53) KMT2AAOC3ALDH1A1GAAKDM4E
SCHEMBL31182223 1.00 KMT2A (0.53) KMT2AAOC3ALDH1A1GAAKDM4E
SCHEMBL10154595 0.84 GRIN2D (0.49) AOC3GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL16472352 0.84 GRIN2D (0.49) AOC3GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL20469120 0.84 PIK3CA (0.51) KMT2AAOC3ALDH1A1GAACYP1A2
SCHEMBL14376036 0.82 NR3C2 (0.47) KMT2AAOC3ALDH1A1GAAKDM4E
SCHEMBL18436755 0.81 KMT2A (0.51) KMT2AAOC3ALDH1A1GAAKDM4E
SCHEMBL17803130 0.81 KMT2A (0.51) KMT2AAOC3ALDH1A1GAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3909949-A1 ATAZANAVIR (ATV) ANALOGUES FOR TREATING HIV INFECTIONS Gilead Sciences, Inc. (US) 2021-11-17 EP disclosed