Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15743968 | 1.00 | KMT2A (0.53) | KMT2AAOC3ALDH1A1GAAKDM4E | |
| SCHEMBL24018507 | 1.00 | KMT2A (0.53) | KMT2AAOC3ALDH1A1GAAKDM4E | |
| SCHEMBL18436130 | 1.00 | KMT2A (0.53) | KMT2AAOC3ALDH1A1GAAKDM4E | |
| SCHEMBL31182223 | 1.00 | KMT2A (0.53) | KMT2AAOC3ALDH1A1GAAKDM4E | |
| SCHEMBL10154595 | 0.84 | GRIN2D (0.49) | AOC3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL16472352 | 0.84 | GRIN2D (0.49) | AOC3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20469120 | 0.84 | PIK3CA (0.51) | KMT2AAOC3ALDH1A1GAACYP1A2 | |
| SCHEMBL14376036 | 0.82 | NR3C2 (0.47) | KMT2AAOC3ALDH1A1GAAKDM4E | |
| SCHEMBL18436755 | 0.81 | KMT2A (0.51) | KMT2AAOC3ALDH1A1GAAKDM4E | |
| SCHEMBL17803130 | 0.81 | KMT2A (0.51) | KMT2AAOC3ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230027055-A1 | HIV INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
| US-11078208-B1 | HIV inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2021-08-03 | — | — | US | disclosed |
| US-10294234-B2 | HIV inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2019-05-21 | — | — | US | disclosed |
| EP-2479165-B1 | GLYCINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-10-25 | — | — | EP | disclosed |
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-06-22 | — | — | US | disclosed |
| US-9624229-B2 | Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases | RIGEL PHARMACEUTICALS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-20160264548-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-09-15 | — | — | US | disclosed |
| WO-2015061247-A2 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2015-04-30 | — | — | WO | disclosed |
| US-20140213585-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS, INC. (US) | 2014-07-31 | — | — | US | disclosed |
| US-8735418-B2 | Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases | RIGEL PHARMACEUTICALS, INC. (US) | 2014-05-27 | — | — | US | disclosed |
| US-20090043094-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXYLIC ACID DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| US-20090043094-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXYLIC ACID DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| US-7459580-B2 | Process for trans-4-amino-1-cyclohexanecarboxilic acid derivatives | SHIONOGI & CO., LTD. (JP) | 2008-12-02 | — | — | US | disclosed |
| US-7459580-B2 | Process for trans-4-amino-1-cyclohexanecarboxilic acid derivatives | SHIONOGI & CO., LTD. (JP) | 2008-12-02 | — | — | US | disclosed |
| US-20080262264-A1 | Process For the Preparation of Sulfomate-Carboxylate Derivatives | SHIONOGI & CO., LTD. (JP) | 2008-10-23 | — | — | US | disclosed |
| US-20080262264-A1 | Process For the Preparation of Sulfomate-Carboxylate Derivatives | SHIONOGI & CO., LTD. (JP) | 2008-10-23 | — | — | US | disclosed |
| US-20080039662-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXILIC ACID DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2008-02-14 | — | — | US | disclosed |
| US-20080039662-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXILIC ACID DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2008-02-14 | — | — | US | disclosed |
| US-7314950-B2 | Process for producing trans-4-amino-1-cyclohexanecarboxilic acid derivative | SHIONOGI & CO., LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
| US-7314950-B2 | Process for producing trans-4-amino-1-cyclohexanecarboxilic acid derivative | SHIONOGI & CO., LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264548-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | BTK, SYK, LCK | KMT2A 1229/4885AOC3 3610/4885ALDH1A1 4570/4885 |
| US-20230027055-A1 | HIV INHIBITOR COMPOUNDS | NFATC1, SAMHD1, CCR5 | KMT2A 1636/4885AOC3 4271/4885ALDH1A1 1353/4885 |
| US-20090043094-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXYLIC ACID DERIVATIVES | ACMSD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, AADAT | KMT2A 962/4885AOC3 802/4885ALDH1A1 532/4885 |
| US-20140213585-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | JAK2, JAK1, JAK3 | KMT2A 404/4885AOC3 2427/4885ALDH1A1 3219/4885 |
| US-11078208-B1 | HIV inhibitor compounds | NFATC1, SAMHD1, CCR5 | KMT2A 1636/4885AOC3 4271/4885ALDH1A1 1353/4885 |
| US-20080039662-A1 | PROCESS FOR TRANS-4-AMINO-1-CYCLOHEXANECARBOXILIC ACID DERIVATIVES | AADAT, ACMSD, AAAS | KMT2A 797/4885AOC3 759/4885ALDH1A1 679/4885 |
| US-20080262264-A1 | Process For the Preparation of Sulfomate-Carboxylate Derivatives | STS, ADH1C, ADH1A | KMT2A 1161/4885AOC3 162/4885ALDH1A1 48/4885 |
| US-20170174703-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | SMO, GLI1, SHH | KMT2A 325/4885AOC3 3530/4885ALDH1A1 892/4885 |
| US-10294234-B2 | HIV inhibitor compounds | NFATC1, SAMHD1, CCR5 | KMT2A 1636/4885AOC3 4271/4885ALDH1A1 1353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.