Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.37 |
| ▸ | KDM1A | O60341 | 4/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21336962 | 0.82 | HRH4 (0.40) | HRH4CYP11B2KDM1AKDM4AKDM5B | |
| SCHEMBL17128231 | 0.81 | BRS3 (0.45) | HRH4CYP11B2CYP11B1KDM4AKDM5B | |
| SCHEMBL17128238 | 0.80 | PDE5A (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL18436887 | 0.79 | HRH4 (0.42) | HRH4KDM1APRKDC | |
| SCHEMBL17127884 | 0.79 | HRH4 (0.42) | HRH4KDM1APRKDC | |
| SCHEMBL17128081 | 0.79 | HRH4 (0.43) | HRH4KDM1AMAOBPRKDC | |
| SCHEMBL18436763 | 0.78 | HRH4 (0.38) | HRH4CYP11B2KDM1ACYP11B1MAOB | |
| SCHEMBL21336710 | 0.78 | HRH4 (0.40) | HRH4CYP11B2CYP11B1KDM4AKDM5B | |
| SCHEMBL17128328 | 0.77 | HRH4 (0.42) | HRH4CYP11B2KDM1ACYP11B1KDM4A | |
| SCHEMBL17127837 | 0.77 | HRH4 (0.40) | HRH4KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |