Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK3 | P49761 | 12/20 | 0.77 |
| ▸ | CLK2 | P49760 | 11/20 | 0.77 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.77 |
| ▸ | WNT1 | P04628 | 8/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18441881 | 0.96 | CLK3 (0.74) | CLK3CLK2DYRK1AWNT1 | |
| SCHEMBL18441959 | 0.94 | CLK2 (0.85) | CLK3CLK2DYRK1AWNT1 | |
| SCHEMBL18441674 | 0.94 | CLK3 (0.79) | CLK3CLK2DYRK1AWNT1 | |
| SCHEMBL18441793 | 0.92 | CLK2 (0.90) | CLK3CLK2DYRK1AWNT1 | |
| SCHEMBL20965865 | 0.92 | CLK3 (0.68) | CLK3CLK2DYRK1AWNT1 | |
| SCHEMBL18441304 | 0.92 | CLK3 (0.76) | CLK3CLK2DYRK1AWNT1 | |
| SCHEMBL18441797 | 0.92 | CLK3 (0.74) | CLK3CLK2DYRK1AWNT1 | |
| SCHEMBL20965060 | 0.91 | WNT1 (0.83) | CLK3CLK2DYRK1AWNT1 | |
| SCHEMBL18441270 | 0.91 | WNT1 (0.83) | CLK3CLK2DYRK1AWNT1 | |
| SCHEMBL18441717 | 0.91 | CLK2 (0.72) | CLK3CLK2DYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350199-B2 | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof | SAMUMED, LLC (US) | 2019-07-16 | — | — | US | claimed |
| US-20180207141-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2018-07-26 | — | — | US | claimed |
| WO-2017024021-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2017-02-09 | — | — | WO | claimed |
| US-10350199-B2 | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof | SAMUMED, LLC (US) | 2019-07-16 | — | — | US | disclosed |
| US-10350199-B2 | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof | SAMUMED, LLC (US) | 2019-07-16 | — | — | US | disclosed |
| US-20180207141-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2018-07-26 | — | — | US | disclosed |
| US-20180207141-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2018-07-26 | — | — | US | disclosed |
| US-20180207141-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2018-07-26 | — | — | US | disclosed |
| WO-2017024021-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2017-02-09 | — | — | WO | disclosed |
| WO-2017024021-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2017-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10350199-B2 | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof | WNT1, WNT3, WNT3A | CLK3 759/4885CLK2 779/4885DYRK1A 513/4885 |
| US-20180207141-A1 | 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | WNT1, WNT3, WNT3A | CLK3 759/4885CLK2 779/4885DYRK1A 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.