Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10693709 | 0.92 | HDAC1 (0.51) | TMEM97SIGMAR1PARP1KDM4EHDAC1 | |
| SCHEMBL1844965 | 0.92 | HDAC1 (0.51) | TMEM97SIGMAR1PARP1KDM4EHDAC1 | |
| SCHEMBL10690267 | 0.92 | HDAC1 (0.51) | TMEM97SIGMAR1PARP1KDM4EHDAC1 | |
| SCHEMBL14441803 | 0.90 | POLB (0.45) | TMEM97SIGMAR1KDM4EHDAC1HDAC2 | |
| SCHEMBL26374397 | 0.88 | POLB (0.43) | TMEM97SIGMAR1HDAC1HDAC2HDAC8 | |
| SCHEMBL26374313 | 0.88 | HDAC1 (0.54) | TMEM97SIGMAR1PARP1KDM4EHDAC1 | |
| SCHEMBL1843769 | 0.86 | HDAC1 (0.47) | TMEM97SIGMAR1PARP1KDM4EHDAC1 | |
| SCHEMBL1842219 | 0.85 | HDAC1 (0.48) | TMEM97SIGMAR1KDM4EHDAC1HDAC2 | |
| SCHEMBL26643297 | 0.85 | HDAC1 (0.50) | KDM4EHDAC1HDAC2HDAC8POLB | |
| SCHEMBL1842743 | 0.84 | HPGD (0.43) | TMEM97SIGMAR1PARP1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230310640-A1 | PYRROLOBENZODIAZEPINE DERIVATIVE AND LIGAND-LINKER CONJUGATE THEREOF | LEGOCHEM BIOSCIENCES, INC. (KR) | 2023-10-05 | — | — | US | disclosed |
| WO-2021137646-A1 | PYRROLOBENZODIAZEPINE DERIVATIVE AND LIGAND-LINKER CONJUGATE THEREOF | 주식회사 레고켐바이오사이언스 | 2021-07-08 | — | — | WO | disclosed |
| EP-2066627-B1 | NOVEL MINOR GROOVE BINDERS | UNIV STRATHCLYDE (GB) | 2013-10-23 | — | — | EP | disclosed |
| US-8012967-B2 | Minor groove binders | UNIVERSITY OF STRATHCLYDE (GB) | 2011-09-06 | — | — | US | disclosed |
| EP-1467969-B1 | DNA MINOR GROOVE BINDING COMPOUNDS | UNIV STRATHCLYDE (GB) | 2011-05-18 | — | — | EP | disclosed |
| US-7863455-B2 | Electrochemically active ligand for sequence-specific detection of double-stranded nucleic acid molecule | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-01-04 | — | — | US | disclosed |
| US-7700765-B2 | DNA minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2010-04-20 | — | — | US | disclosed |
| US-20100016311-A1 | NOVEL MINOR GROOVE BINDERS | UNIVERSITY OF STRATHCLYDE (GB) | 2010-01-21 | — | — | US | disclosed |
| EP-2066627-A1 | NOVEL MINOR GROOVE BINDERS | The University of Strathclyde (GB) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008038018-A1 | NOVEL MINOR GROOVE BINDERS | UNIVERSITY OF STRATHCLYDE (GB) | 2008-04-03 | — | — | WO | disclosed |
| US-20070172826-A1 | Electrochemically active ligand for sequence-specific detection of double-stranded nucleic acid molecule | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2007-07-26 | — | — | US | disclosed |
| US-20070117760-A1 | Dna minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2007-05-24 | — | — | US | disclosed |
| US-4766142-A | ANTICARCINOGENIC AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1988-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016311-A1 | NOVEL MINOR GROOVE BINDERS | TOP2B, DNA2, CTCF | TMEM97 1668/4885SIGMAR1 766/4885PARP1 431/4885 |
| US-20070172826-A1 | Electrochemically active ligand for sequence-specific detection of double-stranded nucleic acid molecule | POLRMT, POLM, POLI | TMEM97 890/4885SIGMAR1 496/4885PARP1 426/4885 |
| US-20070117760-A1 | Dna minor groove binding compounds | PCNA, POLL, POLM | TMEM97 4618/4885SIGMAR1 2601/4885PARP1 275/4885 |
| US-20230310640-A1 | PYRROLOBENZODIAZEPINE DERIVATIVE AND LIGAND-LINKER CONJUGATE THEREOF | BCR, PDCD1LG2, PRLHR | TMEM97 2319/4885SIGMAR1 2494/4885PARP1 682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.