Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 3/20 | 0.35 |
| ▸ | GIPR | P48546 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1844250 | 0.93 | ADORA3 (0.38) | PTGESADORA3MCHR1LMNAPPARD | |
| SCHEMBL1845327 | 0.89 | PSEN1 (0.42) | PTGESADORA3MCHR1PPARDPPARG | |
| SCHEMBL1843583 | 0.86 | PSEN1 (0.39) | PTGESPPARDPPARGPPARAPSEN1 | |
| SCHEMBL27819792 | 0.85 | ADORA3 (0.38) | PTGESADORA3MCHR1PPARDPPARG | |
| SCHEMBL1847657 | 0.81 | ADORA3 (0.50) | PTGESADORA3LMNAPPARDTP53 | |
| SCHEMBL1844715 | 0.79 | PSEN1 (0.57) | ADORA3MCHR1PPARDPPARGPPARA | |
| SCHEMBL27839264 | 0.78 | ADORA3 (0.39) | PTGESADORA3MCHR1PPARDPPARA | |
| SCHEMBL1843439 | 0.78 | LMNA (0.47) | PTGESADORA3LMNAPPARDTP53 | |
| SCHEMBL1841633 | 0.77 | L3MBTL1 (0.54) | ADORA3LMNAPPARDTP53SMN1; SMN2 | |
| SCHEMBL1845846 | 0.77 | ADORA3 (0.46) | PTGESADORA3LMNAPPARDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968725-B2 | Pyridinyl modulators of γ-secretase | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-06-28 | — | — | US | disclosed |
| EP-2321278-A2 | PYRIDINYL MODULATORS OF y-SECRETASE | Janssen Pharmaceutica, N.V. (BE) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010011626-A2 | PYRIDINYL MODULATORS OF ϒ-SECRETASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| US-20100022583-A1 | PYRIDINYL MODULATORS OF gamma-SECRETASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022583-A1 | PYRIDINYL MODULATORS OF gamma-SECRETASE | BACE1, PSEN1, BACE2 | PTGES 1431/4885ADORA3 126/4885MCHR1 3799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.