Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1847423 | 0.75 | POLB (0.41) | ALDH1A1HTTCYP1A2SMN1; SMN2POLB | |
| SCHEMBL1847166 | 0.69 | ALDH1A1 (0.43) | ALDH1A1CYP1A2SMN1; SMN2CYP2C19HPGD | |
| Hydrochloric Acid SCHEMBL8809398 | 0.68 | ALDH1A1 (0.42) | ALDH1A1CYP1A2SMN1; SMN2CYP2C19KDM4E | |
| SCHEMBL28469771 | 0.67 | MEN1 (0.58) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1845316 | 0.65 | POLB (0.39) | ALDH1A1CYP1A2SMN1; SMN2POLBMEN1 | |
| SCHEMBL15246924 | 0.64 | ALDH1A1 (0.52) | ALDH1A1HTTCYP1A2SMN1; SMN2POLB | |
| SCHEMBL15780901 | 0.63 | ALDH1A1 (0.46) | ALDH1A1HTTCYP1A2SMN1; SMN2POLB | |
| SCHEMBL9686746 | 0.62 | ALDH1A1 (0.43) | ALDH1A1CYP1A2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL24359166 | 0.62 | KDM4E (0.76) | ALDH1A1HTTCYP1A2SMN1; SMN2KMT2A | |
| SCHEMBL1707790 | 0.61 | ALDH1A1 (0.49) | ALDH1A1HTTCYP1A2SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324023-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA (US) | 2011-05-25 | — | — | EP | claimed |
| WO-2009070164-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA (US) | 2009-06-04 | — | — | WO | claimed |
| US-20080124306-A1 | Vigor Enhancement Via Administration of Pyrimidine Derivatives | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2008-05-29 | — | — | US | claimed |
| US-20230302000-A1 | COMBINATION DRUG TREATMENT TO INCREASE NEUROGENESIS FOR NEUROLOGICAL DISORDERS | Progenicyte Therapeutics, Inc. (US) | 2023-09-28 | — | — | US | disclosed |
| US-20210046079-A1 | COMBINATION THERAPY TO IMPROVE BRAIN FUNCTION OR PROMOTE NEUROGENESIS FOR TREATING NEURODEGENERATIVE CONDITIONS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2021-02-18 | — | — | US | disclosed |
| US-20200246334-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2020-08-06 | — | — | US | disclosed |
| US-20190167674-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2019-06-06 | — | — | US | disclosed |
| US-20180092913-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2018-04-05 | — | — | US | disclosed |
| EP-2326330-B1 | COMPOSITIONS FOR TREATING OR DELAYING THE ONSET OF HAIR LOSS | UNIV CENTRAL FLORIDA RES FOUND (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8791128-B2 | Compositions for treating or delaying the onset of hair loss | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-07-29 | — | — | US | disclosed |
| US-20110190320-A1 | Compositions for Treating or Delaying the Onset of Hair Loss | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2011-08-04 | — | — | US | disclosed |
| EP-2326330-A1 | COMPOSITIONS FOR TREATING OR DELAYING THE ONSET OF HAIR LOSS | University Of Central Florida Research Foundation, Inc. (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010087527-A1 | ULTRAVIOLET ABSORBERS, AND PHARMACEUTICAL COMPOSITIONS AND COSMETICS CONTAINING PYRIMIDINE COMPOUNDS FOR UV PROTECTION | AWAYA AKIRA (JP) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010033576-A1 | COMPOSITIONS FOR TREATING OR DELAYING THE ONSET OF HAIR LOSS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-03-25 | — | — | WO | disclosed |
| US-20090087462-A1 | Use of pyrimidine derivatives for cosmetic purposes | TREMBLEY MARCELLA | 2009-04-02 | — | — | US | disclosed |
| US-20080124306-A1 | Vigor Enhancement Via Administration of Pyrimidine Derivatives | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2008-05-29 | — | — | US | disclosed |
| EP-1890673-A1 | USE OF PYRIMIDINE DERIVATIVES FOR COSMETIC PURPOSES | DSMIP Assets B.V. (NL) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006133876-A1 | USE OF PYRIMIDINE DERIVATIVES FOR COSMETIC PURPOSES | DSM IP ASSETS B.V. (NL) | 2006-12-21 | — | — | WO | disclosed |
| US-5976523-A | PIPERIDINE- OR PIPERAZINE-SUBSTITUTED PYRROLOPYRIMIDINES | MITSUI PHARMACEUTICALS, INC. (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0743066-A2 | Wound-healing agent | MITSUI PHARMACEUTICALS, INC. (JP) | 1996-11-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080124306-A1 | Vigor Enhancement Via Administration of Pyrimidine Derivatives | TYMP, SLC18A3, SLC18A2 | ALDH1A1 318/4885HTT 1745/4885CYP1A2 800/4885 |
| US-20190167674-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | TYMP, SLC18A3, SLC18A2 | ALDH1A1 318/4885HTT 1745/4885CYP1A2 800/4885 |
| US-20210046079-A1 | COMBINATION THERAPY TO IMPROVE BRAIN FUNCTION OR PROMOTE NEUROGENESIS FOR TREATING NEURODEGENERATIVE CONDITIONS | PSEN1, PSEN2, NES | ALDH1A1 4397/4885HTT 53/4885CYP1A2 4466/4885 |
| US-20090087462-A1 | Use of pyrimidine derivatives for cosmetic purposes | TYMP, TYMS, UNG | ALDH1A1 1067/4885HTT 1130/4885CYP1A2 1110/4885 |
| US-20110190320-A1 | Compositions for Treating or Delaying the Onset of Hair Loss | SHBG, CYP19A1, TYMP | ALDH1A1 1649/4885HTT 3798/4885CYP1A2 1268/4885 |
| US-20180092913-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | TYMP, SLC18A3, SLC18A2 | ALDH1A1 318/4885HTT 1745/4885CYP1A2 800/4885 |
| US-20230302000-A1 | COMBINATION DRUG TREATMENT TO INCREASE NEUROGENESIS FOR NEUROLOGICAL DISORDERS | NES, PSEN1, PSEN2 | ALDH1A1 2409/4885HTT 288/4885CYP1A2 4390/4885 |
| US-20200246334-A1 | VIGOR ENHANCEMENT VIA ADMINISTRATION OF PYRIMIDINE DERIVATIVES | TYMP, SLC18A3, SLC18A2 | ALDH1A1 318/4885HTT 1745/4885CYP1A2 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.