Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 15/20 | 0.55 |
| ▸ | CLK3 | P49761 | 14/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 14/20 | 0.55 |
| ▸ | WNT1 | P04628 | 5/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18453766 | 0.93 | CLK2 (0.64) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL18451763 | 0.92 | CLK2 (0.64) | CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL18437177 | 0.91 | CLK2 (0.52) | CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL18447220 | 0.91 | CLK2 (0.56) | CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL18448631 | 0.90 | WNT1 (0.58) | CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL18452621 | 0.89 | CLK2 (0.63) | CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL18452137 | 0.89 | CLK2 (0.58) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL18483276 | 0.88 | CLK2 (0.48) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL18452197 | 0.88 | CLK2 (0.61) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL18447645 | 0.88 | CLK2 (0.67) | CLK2CLK3DYRK1AWNT1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180221352-A1 | 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC | 2018-08-09 | — | — | US | claimed |
| WO-2017023981-A1 | 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | claimed |
| US-20180221352-A1 | 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC | 2018-08-09 | — | — | US | disclosed |
| US-20180221352-A1 | 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC | 2018-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180221352-A1 | 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | WNT1, WNT3A, WNT3 | CLK2 2019/4885CLK3 2160/4885DYRK1A 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.