Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857993 | 0.81 | ALDH1A1 (0.64) | KMT2AMEN1ALDH1A1PKMHTR6 | |
| SCHEMBL9178059 | 0.71 | ALDH1A1 (0.64) | ALDH1A1PKMBRD4CYP19A1LMNA | |
| SCHEMBL3854458 | 0.70 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1PKMBRD4 | |
| SCHEMBL28383011 | 0.68 | DRD2 (0.58) | ALDH1A1BRD4CYP19A1HTR6LMNA | |
| SCHEMBL30326699 | 0.68 | DRD2 (0.58) | ALDH1A1BRD4CYP19A1HTR6LMNA | |
| SCHEMBL732734 | 0.68 | HTR6 (0.64) | KMT2AMEN1ALDH1A1PKMBRD4 | |
| SCHEMBL1422203 | 0.68 | HTR6 (0.55) | PKMHTR6 | |
| SCHEMBL1422454 | 0.68 | HTR6 (0.70) | HTR6 | |
| Hydrochloric Acid SCHEMBL1881394 | 0.67 | HTR6 (0.56) | PKMHTR6 | |
| SCHEMBL28379967 | 0.66 | HSD17B2 (0.56) | KMT2AALDH1A1PKMLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324035-A1 | SUBSTITUTED N-PHENYL-2,3-DIHYDROIMIDAZO[2,1-B]THIAZOLE-5-SULFONAMIDE DERIVATIVES AS 5-HT6 LIGANDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-05-25 | — | — | EP | disclosed |