Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 0.59 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13562542 | 0.86 | NPBWR1 (0.63) | NPBWR1MCHR1TSHRSMN1; SMN2HTT | |
| SCHEMBL18446182 | 0.83 | NPC1 (0.64) | NPBWR1MCHR1TSHRLMNASMN1; SMN2 | |
| SCHEMBL11049861 | 0.79 | ALDH1A1 (0.54) | NPBWR1LMNASMN1; SMN2HTTCYP1A2 | |
| SCHEMBL3028836 | 0.78 | ALDH1A1 (0.63) | NPBWR1MCHR1TSHRLMNASMN1; SMN2 | |
| SCHEMBL3041881 | 0.78 | NPBWR1 (0.72) | NPBWR1MCHR1LMNASMN1; SMN2HTT | |
| SCHEMBL18467391 | 0.76 | SMN1; SMN2 (0.54) | NPBWR1TSHRLMNASMN1; SMN2HTT | |
| SCHEMBL30783355 | 0.76 | TSHR (0.55) | NPBWR1MCHR1TSHRLMNASMN1; SMN2 | |
| SCHEMBL30783278 | 0.74 | SMN1; SMN2 (0.50) | NPBWR1MCHR1TSHRLMNASMN1; SMN2 | |
| SCHEMBL18467907 | 0.73 | CNR2 (0.48) | NPBWR1MCHR1LMNASMN1; SMN2HTT | |
| SCHEMBL6313505 | 0.71 | RAB9A (0.67) | LMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2518063-B1 | Pyridazinones and furan-containing compounds | SLOAN-KETTERING INST FOR CANCER RES (US) | 2017-02-01 | — | — | EP | disclosed |