Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.78 |
| ▸ | MAPT | P10636 | 10/20 | 0.78 |
| ▸ | LMNA | P02545 | 6/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.78 |
| ▸ | NPC1 | O15118 | 3/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.78 |
| ▸ | RAB9A | P51151 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 3/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | HTR6 | P50406 | 4/20 | 0.64 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1845563 | 0.92 | MAPT (0.68) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL1844422 | 0.90 | ALDH1A1 (0.80) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL1844113 | 0.88 | HTR6 (0.73) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL1841808 | 0.87 | ALDH1A1 (0.76) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL2181933 | 0.87 | MAPT (0.86) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL1844975 | 0.86 | DCTPP1 (0.78) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL2762508 | 0.86 | DCTPP1 (0.72) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL1844129 | 0.85 | HTR6 (0.67) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL1844684 | 0.85 | MAPT (0.68) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL1844857 | 0.85 | HTR6 (0.66) | ALDH1A1MAPTLMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320897-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | Treventis Corporation (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010025375-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | TREVENTIS CORPORATION (US) | 2010-03-04 | — | — | WO | disclosed |