Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 12/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CAD | P27708 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18455838 | 0.84 | CASP1 (0.43) | SMN1; SMN2ALDH1A1CASP1MAPT | |
| SCHEMBL9698253 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1CASP1CYP1A2CYP2C9 | |
| SCHEMBL15107083 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1CASP1 | |
| SCHEMBL6295271 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1CASP1NPSR1MAPT | |
| SCHEMBL13067403 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1CASP1CYP2C9L3MBTL1 | |
| SCHEMBL13026177 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1CASP1CYP2C9L3MBTL1 | |
| SCHEMBL16772844 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1CASP1HTTNPSR1 | |
| SCHEMBL18455295 | 0.73 | CTSL (0.53) | ALDH1A1 | |
| SCHEMBL13205568 | 0.73 | ALDH1A1 (0.61) | ALDH1A1CASP1 | |
| SCHEMBL9403524 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852573-B1 | N-[3-(2-CARBOXYETHYL)PHENYL]-PIPERIDIN-1-YL ACETAMIDE DERIVATIVES AND THEIR USE AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | Bayer Pharma AG (DE) | 2017-02-01 | — | — | EP | disclosed |