Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24353248 | 0.89 | PKM (0.43) | PKMKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL24353180 | 0.88 | LMNA (0.43) | PKMKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL24353221 | 0.86 | PDE4A (0.45) | PKMKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL24353217 | 0.85 | PKM (0.40) | PKMKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL24353322 | 0.84 | ALDH1A1 (0.46) | PKMKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL24353218 | 0.84 | ALDH1A1 (0.46) | PKMKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL24353182 | 0.83 | ALDH1A1 (0.44) | PKMKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL24353229 | 0.82 | ALDH1A1 (0.43) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL24353318 | 0.82 | ALDH1A1 (0.48) | LMNAALDH1A1HTT | |
| SCHEMBL18456744 | 0.82 | ALDH1A1 (0.43) | KMT2AMEN1LMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017019537-A1 | COMPOUNDS, COMPOSITIONS, METHODS FOR TREATING DISEASES, AND METHODS FOR PREPARING COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2017-02-02 | — | — | WO | disclosed |