Cadaverine Tartrate

Cadaverine Tartrate

SCHEMBL1845813

C1CNCCN1.O=C([O-])C(O)C(O)C(=O)O.[K+]

nearest known ligand 0.48

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Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3BCHECHRM1CHRM2CHRM3CHRM4CHRNA3CHRNA4CHRNB2CHRNB4ESR1ESR2GABRA1GABRB1GABRG2GBA1GHSRHRH1HTR1DHTR2AMAOBOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8UGCGrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GBA1 known ✓ P04062 1/20 0.39
GABRA1 known ✓ P14867 1/20 0.31
GABRB1 known ✓ P18505 1/20 0.31
GABRG2 known ✓ P18507 1/20 0.31
TSHR P16473 4/20 0.48
LMNA P02545 2/20 0.42
PMP22 Q01453 2/20 0.42
CYP3A4 P08684 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
BLM P54132 1/20 0.42
NFKB1 P19838 1/20 0.32
CYP2C19 P33261 1/20 0.32
CPN1 P15169 1/20 0.31
CPB2 Q96IY4 1/20 0.31
GABRP O00591 1/20 0.31
GABRD O14764 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cadaverine Tartrate SCHEMBL1845816 0.93 TSHR (0.35) TSHRLMNAPMP22CYP3A4TDP1
Cadaverine Tartrate SCHEMBL5874937 0.87 TSHR (0.62) TSHRLMNAPMP22CYP3A4TDP1
Cadaverine Tartrate SCHEMBL1642932 0.87 TSHR (0.62) TSHRLMNAPMP22CYP3A4TDP1
Cadaverine Tartrate SCHEMBL31321715 0.87 TSHR (0.62) TSHRLMNAPMP22CYP3A4TDP1
Cadaverine Tartrate SCHEMBL35445 0.84 TSHR (0.67) TSHRLMNAPMP22CYP3A4TDP1
Cadaverine Tartrate SCHEMBL9446378 0.84 TSHR (0.67) TSHRLMNAPMP22CYP3A4TDP1
Cadaverine Tartrate SCHEMBL263269 0.84 TSHR (0.67) TSHRLMNAPMP22CYP3A4TDP1
Cadaverine Tartrate SCHEMBL20565539 0.84 TSHR (0.67) TSHRLMNAPMP22CYP3A4TDP1
Cadaverine Tartrate SCHEMBL263268 0.84 TSHR (0.67) TSHRLMNAPMP22CYP3A4TDP1
Cadaverine Tartrate SCHEMBL3209520 0.84 TSHR (0.67) TSHRLMNAPMP22CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11154484-B2 Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof ALLERGAN HOLDINGS FRANCE S.A.S. (FR) 2021-10-26 US disclosed
EP-3184552-B1 THREADS OF HYALURONIC ACID, METHODS OF MAKING THEREOF AND USES THEREOF TAUTONA GROUP LP (US) 2020-08-12 EP disclosed
EP-3243533-B1 THREADS OF CROSS-LINKED HYALURONIC ACID AND METHODS OF USE THEREOF ALLERGAN HOLDINGS FRANCE S A S (FR) 2020-06-17 EP disclosed
US-10463595-B2 Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof ALLERGAN HOLDINGS FRANCE S.A.S. (FR) 2019-11-05 US disclosed
US-20180344610-A1 THREADS OF HYALURONIC ACID AND/OR DERIVATIVES THEREOF, METHODS OF MAKING THEREOF AND USES THEREOF TAUTONA GROUP LP 2018-12-06 US disclosed
US-9861570-B2 Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof ALLERGAN HOLDINGS FRANCE S.A.S. (FR) 2018-01-09 US disclosed
EP-3243533-A1 THREADS OF CROSS-LINKED HYALURONIC ACID AND METHODS OF USE THEREOF Allergan Holdings France S.A.S. (FR) 2017-11-15 EP disclosed
EP-2324064-B1 THREADS OF HYALURONIC ACID AND/OR DERIVATIVES THEREOF, METHODS OF MAKING THEREOF AND USES THEREOF TAUTONA GROUP LP (US) 2017-11-08 EP disclosed
EP-2979709-B1 THREADS OF CROSS-LINKED HYALURONIC ACID AND USE THEREOF ALLERGAN HOLDINGS FRANCE S A S (FR) 2017-08-02 EP disclosed
EP-3184552-A1 THREADS OF HYALURONIC ACID AND/OR DERIVATIVES THEREOF, METHODS OF MAKING THEREOF AND USES THEREOF Tautona Group LP (US) 2017-06-28 EP disclosed
US-20130122068-A1 THREADS OF CROSS-LINKED HYALURONIC ACID AND METHODS OF USE THEREOF TAUTONA GROUP LP (US) 2013-05-16 US disclosed
WO-2013055832-A1 THREADS OF CROSS-LINKED HYALURONIC ACID AND METHODS OF USE THEREOF TAUTONA GROUP LP (US) 2013-04-18 WO disclosed
WO-2012054311-A1 THREADS OF CROSS-LINKED HYALURONIC ACID AND METHODS OF PREPARATION AND USE THEREOF TAUTONA GROUP LP (US) 2012-04-26 WO disclosed
WO-2012054301-A1 SOFT TISSUE AUGMENTATION THREADS AND METHODS OF USE THEREOF TAUTONA GROUP LP (US) 2012-04-26 WO disclosed
US-20110263724-A1 THREADS OF HYALURONIC ACID AND/OR DERIVATIVES, THEREOF, METHODS OF MAKING THEREOF AND USES THEREOF ALINE AESTHETICS, LLC 2011-10-27 US disclosed
WO-2011109129-A1 THREADS OF CROSS-LINKED HYALURONIC ACID AND METHODS OF USE THEREOF TAUTONA GROUP LP (US) 2011-09-09 WO disclosed
WO-2011109130-A1 THREADS OF HYALURONIC ACID AND METHODS OF USE THEREOF TAUTONA GROUP LP (US) 2011-09-09 WO disclosed
EP-2324064-A1 THREADS OF HYALURONIC ACID AND/OR DERIVATIVES THEREOF, METHODS OF MAKING THEREOF AND USES THEREOF Tautona Group LP (US) 2011-05-25 EP disclosed
WO-2010028025-A1 THREADS OF HYALURONIC ACID AND/OR DERIVATIVES THEREOF, METHODS OF MAKING THEREOF AND USES THEREOF GURTNER GEOFFREY C (US) 2010-03-11 WO disclosed
WO-2010017526-A1 PURINE NUCLEOTIDES ISOTOPICALLY LABELED IN THE PURINE BASE, METHODS OF MAKING THEREOF AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2010-02-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130122068-A1 THREADS OF CROSS-LINKED HYALURONIC ACID AND METHODS OF USE THEREOF CUTA, DSG1, COL14A1 GBA1 3481/4885GABRA1 3598/4885GABRB1 4082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.