Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.44 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.44 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.44 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.44 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.44 |
| ▸ | ATP1B3 | P54709 | 3/20 | 0.44 |
| ▸ | FXYD2 | P54710 | 3/20 | 0.44 |
| ▸ | ATP1A4 | Q13733 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786576 | 1.00 | GAA (0.46) | GAASMN1; SMN2LMNAHSD17B10ATP1A1 | |
| SCHEMBL3780558 | 0.79 | ADRA2A (0.44) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1845819 | 0.79 | KDM4E (0.46) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL1843836 | 0.79 | ADRA2A (0.44) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL3784547 | 0.79 | KDM4E (0.46) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL1844707 | 0.78 | ADRA2A (0.51) | HSD17B10HPGDADRA2AADRA2CADRA1D | |
| SCHEMBL1844705 | 0.78 | ADRA2A (0.51) | HSD17B10HPGDADRA2AADRA2CADRA1D | |
| SCHEMBL2625552 | 0.75 | — | — | |
| SCHEMBL15131086 | 0.72 | TAAR1 (0.55) | SMN1; SMN2LMNAALDH1A1ADRA2AADRA1A | |
| SCHEMBL1844522 | 0.72 | ADRA2A (0.53) | LMNAALDH1A1ADRA2AADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101557810-B | Novel 2 -imidazoles as ligands for trace amine associated receptors (taar) | HOFFMANN LA ROCHE | 2012-11-21 | — | — | CN | claimed |
| EP-2101762-B1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | HOFFMANN LA ROCHE (CH) | 2011-05-18 | — | — | EP | claimed |
| US-7858653-B2 | 2-imidazoles | HOFFMAN-LA ROCHE INC. (US) | 2010-12-28 | — | — | US | claimed |
| CN-101557810-A | Novel 2 -imidazoles as ligands for trace amine associated receptors (taar) | HOFFMANN LA ROCHE (CH) | 2009-10-14 | — | — | CN | claimed |
| US-20080146634-A1 | 2-IMIDAZOLES | HOFFMANN-LA ROCHE INC. | 2008-06-19 | — | — | US | claimed |
| US-4411700-A | AMIDINE DERIVATIVES | FUJI PHOTO FILM CO., LTD. (JP) | 1983-10-25 | — | — | US | claimed |
| US-20220280527-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | PURDUE PHARMA L.P. (US) | 2022-09-08 | — | — | US | disclosed |
| US-20190201410-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | PURDUE PHARMA L.P. (US) | 2019-07-04 | — | — | US | disclosed |
| EP-3463359-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | Purdue Pharma LP (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017210616-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | PURDUE PHARMA L.P. (US) | 2017-12-07 | — | — | WO | disclosed |
| CN-101557810-B | Novel 2 -imidazoles as ligands for trace amine associated receptors (taar) | HOFFMANN LA ROCHE | 2012-11-21 | — | — | CN | disclosed |
| EP-2101762-B1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | HOFFMANN LA ROCHE (CH) | 2011-05-18 | — | — | EP | disclosed |
| US-7858653-B2 | 2-imidazoles | HOFFMAN-LA ROCHE INC. (US) | 2010-12-28 | — | — | US | disclosed |
| EP-2101762-A1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008071574-A1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008071574-A1 | NOVEL 2 -IMIDAZOLES AS LIGANDS FOR TRACE AMINE ASSOCIATED RECEPTORS (TAAR) | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-19 | — | — | WO | disclosed |
| US-20080146634-A1 | 2-IMIDAZOLES | HOFFMANN-LA ROCHE INC. | 2008-06-19 | — | — | US | disclosed |
| US-20080146634-A1 | 2-IMIDAZOLES | HOFFMANN-LA ROCHE INC. | 2008-06-19 | — | — | US | disclosed |
| US-20080146634-A1 | 2-IMIDAZOLES | HOFFMANN-LA ROCHE INC. | 2008-06-19 | — | — | US | disclosed |
| US-4411700-A | AMIDINE DERIVATIVES | FUJI PHOTO FILM CO., LTD. (JP) | 1983-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190201410-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | TAAR1, TAAR5, OPRL1 | GAA 3298/4885SMN1; SMN2 425/4885LMNA 4352/4885 |
| US-20220280527-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | TAAR1, TAAR5, OPRL1 | GAA 3460/4885SMN1; SMN2 441/4885LMNA 4271/4885 |
| US-20080146634-A1 | 2-IMIDAZOLES | ABL1, H1-2, IPO4 | GAA 1214/4885SMN1; SMN2 2165/4885LMNA 1410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.