Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19328130 | 0.79 | PGK1 (0.44) | GLAMEN1KMT2AEGFRSMN1; SMN2 | |
| SCHEMBL29477047 | 0.78 | CCNA2 (0.48) | GLAMEN1GAAKMT2AEGFR | |
| SCHEMBL19328092 | 0.75 | SMN1; SMN2 (0.47) | GLAGAAEGFRSMN1; SMN2MAPT | |
| SCHEMBL4099333 | 0.75 | DYRK1A (0.41) | GLAEGFRSMN1; SMN2MAPTPKM | |
| SCHEMBL1848870 | 0.74 | NPC1 (0.48) | GAASMN1; SMN2KDM4EPOLBHPGD | |
| SCHEMBL21117070 | 0.74 | KDM4E (0.42) | GAAEGFRSMN1; SMN2MAPTKDM4E | |
| SCHEMBL974622 | 0.74 | PIP4K2A (0.39) | PIP4K2AMEN1GAAKMT2ATBK1 | |
| SCHEMBL16990326 | 0.73 | MAPT (0.37) | GLAGAASMN1; SMN2MAPTPOLB | |
| SCHEMBL31350832 | 0.72 | CHEK1 (0.37) | GLAMEN1KMT2ATBK1EGFR | |
| SCHEMBL17591608 | 0.72 | EGFR (0.37) | TBK1EGFRSMN1; SMN2KDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150368244-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-20150368244-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-20150368244-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| EP-2324024-B1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH INC (US) | 2012-09-26 | — | — | EP | disclosed |
| US-20110124654-A1 | DIAZACARBAZOLES AND METHODS OF USE | ARGENTA DISCOVERY 2009 LIMITED (GB) | 2011-05-26 | — | — | US | disclosed |
| US-20110124654-A1 | DIAZACARBAZOLES AND METHODS OF USE | ARGENTA DISCOVERY 2009 LIMITED (GB) | 2011-05-26 | — | — | US | disclosed |
| US-20110124654-A1 | DIAZACARBAZOLES AND METHODS OF USE | ARGENTA DISCOVERY 2009 LIMITED (GB) | 2011-05-26 | — | — | US | disclosed |
| EP-2324024-A1 | DIAZACARBAZOLES AND METHODS OF USE | Genentech, Inc. (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2009151589-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124654-A1 | DIAZACARBAZOLES AND METHODS OF USE | CHEK1, CHEK2, BUB1B | GLA 2606/4885PIP4K2A 558/4885MEN1 1132/4885 |
| US-20150368244-A1 | DIAZACARBAZOLES AND METHODS OF USE | CHEK1, CHEK2, BUB1B | GLA 2606/4885PIP4K2A 558/4885MEN1 1132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.