Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26304408 | 0.93 | KDM4E (0.38) | KDM4ESMN1; SMN2LOXL2CYP11B1CYP11B2 | |
| SCHEMBL19003682 | 0.86 | LOXL2 (0.38) | KDM4ESMN1; SMN2LOXL2CYP11B1CYP11B2 | |
| SCHEMBL24690502 | 0.84 | TDP1 (0.35) | KDM4ESMN1; SMN2LOXL2 | |
| SCHEMBL21108882 | 0.81 | RPS6KA3 (0.36) | KDM4ESMN1; SMN2LOXL2CYP11B1CYP11B2 | |
| SCHEMBL22260141 | 0.79 | KDM4E (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL24920247 | 0.79 | GAA (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL25025652 | 0.79 | KDM4E (0.37) | KDM4ESMN1; SMN2RPS6KA3 | |
| SCHEMBL19176519 | 0.79 | TDP1 (0.36) | LOXL2RPS6KA3 | |
| SCHEMBL19831937 | 0.79 | KDM4E (0.37) | KDM4ESMN1; SMN2 | |
| SCHEMBL23219667 | 0.79 | LOXL2 (0.40) | KDM4ESMN1; SMN2LOXL2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9561228-B2 | ERK inhibitors and uses thereof | CELGENE AVILOMICS RESEARCH, INC. (US) | 2017-02-07 | — | — | US | disclosed |