Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 2/20 | 0.34 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23219667 | 0.93 | LOXL2 (0.40) | LOXL2KDM4ESMN1; SMN2RPS6KA3LATS1 | |
| SCHEMBL10264269 | 0.89 | LOXL2 (0.42) | LOXL2RPS6KA3LATS1LATS2CYP17A1 | |
| SCHEMBL23219779 | 0.87 | NR1I2 (0.38) | LOXL2RPS6KA3LATS1LATS2 | |
| SCHEMBL18469769 | 0.86 | KDM4E (0.37) | LOXL2KDM4ESMN1; SMN2RPS6KA3CYP11B1 | |
| SCHEMBL25150545 | 0.81 | TDP1 (0.38) | LOXL2KDM4ESMN1; SMN2RPS6KA3LATS1 | |
| SCHEMBL19173619 | 0.81 | KDM4E (0.38) | KDM4ESMN1; SMN2LATS1LATS2 | |
| SCHEMBL21783997 | 0.81 | RPS6KA3 (0.40) | LOXL2KDM4ESMN1; SMN2RPS6KA3LATS1 | |
| SCHEMBL23869499 | 0.80 | TDP1 (0.37) | LOXL2RPS6KA3LATS1LATS2 | |
| SCHEMBL25025652 | 0.79 | KDM4E (0.37) | KDM4ESMN1; SMN2RPS6KA3 | |
| SCHEMBL26304408 | 0.79 | KDM4E (0.38) | LOXL2KDM4ESMN1; SMN2RPS6KA3LATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |