Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dp001. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR known ✓ | P11473 | 6/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dp001 SCHEMBL12961887 | 1.00 | VDR (0.81) | VDR | |
| Dp001 SCHEMBL19988220 | 1.00 | VDR (0.81) | VDR | |
| Dp001 SCHEMBL29645040 | 1.00 | VDR (0.81) | VDR | |
| Dp001 SCHEMBL15371114 | 1.00 | VDR (0.81) | VDR | |
| Dp001 SCHEMBL15371106 | 1.00 | VDR (0.81) | VDR | |
| Dp001 SCHEMBL12932256 | 1.00 | VDR (0.81) | VDR | |
| Dp001 SCHEMBL8303273 | 1.00 | VDR (0.81) | VDR | |
| Dp001 SCHEMBL10307542 | 1.00 | VDR (0.81) | VDR | |
| Dp001 SCHEMBL21206294 | 1.00 | VDR (0.81) | VDR | |
| Dp001 SCHEMBL12332637 | 1.00 | VDR (0.81) | VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688596-B2 | Synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-06-27 | — | — | US | disclosed |
| US-9688596-B2 | Synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-06-27 | — | — | US | disclosed |
| US-20170036977-A1 | SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-METHYLENE ANALOGS OF CALCITRIOL AND RELATED COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-02-09 | — | — | US | disclosed |
| US-20170036977-A1 | SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-METHYLENE ANALOGS OF CALCITRIOL AND RELATED COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170036977-A1 | SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-METHYLENE ANALOGS OF CALCITRIOL AND RELATED COMPOUNDS | CYP24A1, VDR, CYP2R1 | VDR 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.