Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.51 |
| ▸ | BACE1 | P56817 | 10/20 | 0.51 |
| ▸ | BCHE | P06276 | 9/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.45 |
| ▸ | FABP6 | P51161 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18484552 | 0.86 | ACHE (0.49) | ACHEBACE1BCHEGRIN2BCARM1 | |
| SCHEMBL955623 | 0.85 | ACHE (0.62) | ACHEBACE1BCHEGRIN2BCARM1 | |
| SCHEMBL21618396 | 0.84 | ACHE (0.50) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL9965855 | 0.81 | ACHE (0.54) | ACHEBACE1BCHEGRIN2BCARM1 | |
| SCHEMBL14805850 | 0.81 | ALDH1A1 (0.60) | — | |
| SCHEMBL19100319 | 0.81 | FUCA1 (0.48) | ACHEBACE1BCHE | |
| SCHEMBL28701109 | 0.80 | KDM1A (0.42) | ACHEBACE1BCHEGRIN2BCARM1 | |
| SCHEMBL24928272 | 0.78 | ACHE (0.54) | ACHEBACE1BCHEGRIN2BCARM1 | |
| SCHEMBL17320169 | 0.78 | ACHE (0.58) | ACHEBACE1BCHEGRIN2BCARM1 | |
| SCHEMBL25093393 | 0.77 | ACHE (0.50) | ACHEBACE1BCHEGRIN2BCARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KUMQUAT BIOSCIENCES INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KUMQUAT BIOSCIENCES INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20230064360-A1 | HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. | 2023-03-02 | — | — | US | disclosed |
| US-20170037059-A1 | GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KRAS, NRAS, BRAF | ACHE 4819/4885BACE1 2462/4885BCHE 4667/4885 |
| US-20230064360-A1 | HETEROCYCLES AND USES THEREOF | KRAS, HRAS, TP53 | ACHE 4839/4885BACE1 3901/4885BCHE 4311/4885 |
| US-20170037059-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | ACHE 2058/4885BACE1 3790/4885BCHE 1068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.