Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 6/20 | 0.57 |
| ▸ | MMP13 | P45452 | 5/20 | 0.47 |
| ▸ | MMP9 | P14780 | 4/20 | 0.47 |
| ▸ | MMP2 | P08253 | 3/20 | 0.47 |
| ▸ | MMP3 | P08254 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | HPN | P05981 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 4/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18473182 | 0.91 | ADAMTS4 (0.57) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL7890390 | 0.91 | ADAMTS4 (0.57) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL7966457 | 0.79 | ADAMTS4 (0.47) | ADAMTS4CASP3CASP7GFERLMNA | |
| SCHEMBL7879499 | 0.79 | TDP1 (0.55) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL18782168 | 0.76 | CASP3 (0.48) | ADAMTS4MMP9CASP3CASP7GFER | |
| SCHEMBL18471652 | 0.75 | CASP3 (0.69) | ADAMTS4CASP3CASP7GFERCASP1 | |
| SCHEMBL7886597 | 0.75 | CASP3 (0.69) | ADAMTS4CASP3CASP7GFERCASP1 | |
| SCHEMBL19015948 | 0.74 | NPY5R (0.49) | ADAMTS4MMP13MMP9MMP2MMP3 | |
| SCHEMBL19015805 | 0.74 | CASP3 (0.58) | ADAMTS4CASP3CASP7GFERCASP1 | |
| SCHEMBL8284537 | 0.73 | ADAMTS4 (1.00) | ADAMTS4MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562069-B2 | Selective caspase inhibitors and uses thereof | NEW WORLD LABORATORIES INC. (CA) | 2017-02-07 | — | — | US | disclosed |