Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.71 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.71 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766493 | 0.87 | OPRM1 (0.59) | OPRM1OPRK1OPRD1OPRL1CSF1R | |
| SCHEMBL14280684 | 0.84 | OPRM1 (1.00) | OPRM1OPRK1OPRD1OPRL1CSF1R | |
| SCHEMBL18440866 | 0.84 | OPRM1 (0.54) | OPRM1OPRK1OPRD1OPRL1CSF1R | |
| SCHEMBL18441308 | 0.83 | OPRM1 (0.53) | OPRM1OPRK1OPRD1OPRL1CSF1R | |
| Acetic Acid SCHEMBL11875354 | 0.80 | OPRM1 (0.53) | OPRM1OPRK1OPRD1OPRL1CSF1R | |
| SCHEMBL8726509 | 0.78 | LMNA (0.51) | OPRM1OPRK1OPRD1OPRL1HTR2A | |
| SCHEMBL4774609 | 0.74 | OPRM1 (0.54) | OPRM1OPRK1OPRD1OPRL1MEN1 | |
| SCHEMBL13809832 | 0.73 | OPRM1 (0.41) | OPRM1OPRK1OPRD1OPRL1CSF1R | |
| SCHEMBL4849368 | 0.73 | CSF1R (1.00) | OPRM1OPRK1OPRD1OPRL1CSF1R | |
| SCHEMBL4844308 | 0.73 | CSF1R (1.00) | OPRM1OPRK1OPRD1OPRL1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023894-A1 | MTHFD2 INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-02-09 | — | — | WO | disclosed |