Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 5/20 | 1.00 |
| ▸ | OPRL1 | P41146 | 5/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 2/20 | 1.00 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14529388 | 0.88 | OPRM1 (0.79) | OPRM1OPRK1OPRL1OPRD1TLR9 | |
| SCHEMBL18474336 | 0.84 | OPRM1 (0.71) | OPRM1OPRK1OPRL1OPRD1MEN1 | |
| SCHEMBL14280680 | 0.75 | OPRM1 (1.00) | OPRM1OPRK1OPRL1OPRD1MEN1 | |
| SCHEMBL4766493 | 0.75 | OPRM1 (0.59) | OPRM1OPRK1OPRL1OPRD1TLR9 | |
| SCHEMBL14280681 | 0.74 | OPRM1 (0.79) | OPRM1OPRK1OPRL1OPRD1TLR9 | |
| SCHEMBL11035627 | 0.72 | OPRM1 (0.62) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL11863462 | 0.71 | DRD2 (0.62) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL4774609 | 0.70 | OPRM1 (0.54) | OPRM1OPRK1OPRL1OPRD1TLR9 | |
| SCHEMBL18440866 | 0.70 | OPRM1 (0.54) | OPRM1OPRK1OPRL1OPRD1MEN1 | |
| SCHEMBL38665793 | 0.70 | OPRM1 (0.54) | OPRM1OPRK1OPRL1OPRD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | US | disclosed |
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | OGFRL1, OPRL1, ORMDL3 | OPRM1 11/4885OPRK1 5/4885OPRL1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.