Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | LTA4H | P09960 | 6/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.48 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306311 | 0.87 | NPC1 (0.49) | KDM4EALDH1A1SMN1; SMN2LTA4HHRH3 | |
| SCHEMBL18474438 | 0.82 | LTA4H (0.55) | KDM4EALDH1A1SMN1; SMN2LTA4HHRH3 | |
| SCHEMBL17571469 | 0.82 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2LTA4HHRH3 | |
| SCHEMBL17555438 | 0.79 | LTA4H (0.55) | KDM4EALDH1A1SMN1; SMN2LTA4HHRH3 | |
| SCHEMBL18480195 | 0.79 | LTA4H (0.55) | KDM4EALDH1A1SMN1; SMN2LTA4HHRH3 | |
| SCHEMBL17562439 | 0.78 | KDM4E (0.63) | KDM4EALDH1A1SMN1; SMN2LTA4HPSMB1 | |
| SCHEMBL305458 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1SMN1; SMN2LTA4HHRH3 | |
| SCHEMBL14970709 | 0.77 | KDM4E (0.97) | KDM4EALDH1A1SMN1; SMN2LTA4HHRH3 | |
| SCHEMBL13766268 | 0.77 | KDM4E (0.97) | KDM4EALDH1A1SMN1; SMN2LTA4HHRH3 | |
| SCHEMBL301254 | 0.76 | HRH3 (0.77) | KDM4EALDH1A1SMN1; SMN2LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017024015-A1 | 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |
| WO-2017023987-A1 | 3-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |
| WO-2017023973-A1 | 3-(1H-INDOL-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |
| WO-2017023986-A1 | 3-(1H-INDOL-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2017-02-09 | — | — | WO | disclosed |
| WO-2017023975-A1 | 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |
| WO-2017023993-A1 | 3-(1H-INDOL-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |