Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2762557 | 0.86 | HTR6 (0.56) | HTR6LRRK2KDM4EMEN1ALDH1A1 | |
| SCHEMBL7930794 | 0.80 | HTR6 (0.53) | HTR6LRRK2TLR9TLR7KDM4E | |
| SCHEMBL2767207 | 0.80 | SLC6A4 (0.59) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2766477 | 0.80 | HTR1A (0.59) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL8888785 | 0.79 | HTR1A (0.61) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19381516 | 0.78 | HTR1A (0.67) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23259461 | 0.77 | HTR1A (0.55) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19381132 | 0.77 | HTR1A (0.66) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1845491 | 0.75 | HTR6 (0.59) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23259451 | 0.74 | LRRK2 (0.62) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102170882-A | Compositions and methods of treating amyloid disease | TREVENTIS CORP | 2011-08-31 | — | — | CN | disclosed |
| EP-2320897-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | Treventis Corporation (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010025375-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | TREVENTIS CORPORATION (US) | 2010-03-04 | — | — | WO | disclosed |