Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1315758 | 0.88 | LRRK2 (0.61) | LRRK2CYP3A4SLCO1B1MEN1KMT2A | |
| SCHEMBL552011 | 0.86 | LRRK2 (0.62) | LRRK2CYP3A4SLCO1B1MEN1KMT2A | |
| SCHEMBL1647233 | 0.86 | LRRK2 (0.62) | LRRK2HTR1ASLC6A4CYP3A4SLCO1B1 | |
| SCHEMBL23259450 | 0.86 | ME2 (0.57) | LRRK2MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL7090795 | 0.83 | LRRK2 (0.46) | LRRK2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2303266 | 0.79 | ALDH1A1 (0.61) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL15127660 | 0.78 | ALDH1A1 (0.54) | LRRK2HTR1ASLC6A4CYP3A4SLCO1B1 | |
| SCHEMBL2766477 | 0.78 | HTR1A (0.59) | LRRK2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2767207 | 0.78 | SLC6A4 (0.59) | LRRK2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1316513 | 0.78 | LRRK2 (0.63) | LRRK2CYP3A4SLCO1B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127266-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-04-28 | — | — | US | disclosed |
| US-11225480-B2 | Malic enzyme inhibitors | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-01-18 | — | — | US | disclosed |
| WO-2021074898-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2021-04-22 | — | — | WO | disclosed |
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | LRRK2 953/4885HTR1A 4870/4885SLC6A2 4562/4885 |
| US-11225480-B2 | Malic enzyme inhibitors | ME1, RNASE1, ME2 | LRRK2 693/4885HTR1A 4766/4885SLC6A2 4426/4885 |
| US-20220127266-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | LRRK2 953/4885HTR1A 4870/4885SLC6A2 4562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.