Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 9/20 | 0.62 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853402 | 0.91 | GPR52 (0.75) | GPR52S1PR5S1PR4NR4A2 | |
| SCHEMBL1850704 | 0.88 | GPR52 (0.60) | GPR52S1PR5S1PR4KDM4EMEN1 | |
| SCHEMBL1854351 | 0.85 | GPR52 (0.85) | GPR52S1PR5S1PR4MRGPRX4CDK8 | |
| SCHEMBL1849956 | 0.84 | GPR52 (0.86) | GPR52S1PR5S1PR4MRGPRX4 | |
| SCHEMBL1854277 | 0.82 | S1PR5 (0.63) | GPR52S1PR5S1PR4LIPG | |
| SCHEMBL1849010 | 0.82 | GPR52 (0.54) | GPR52S1PR5S1PR4NR4A2MRGPRX4 | |
| SCHEMBL1850062 | 0.82 | MRGPRX4 (0.57) | GPR52S1PR5S1PR4NR4A2MRGPRX4 | |
| SCHEMBL1852578 | 0.82 | GPR52 (0.61) | GPR52S1PR5S1PR4 | |
| SCHEMBL1852567 | 0.82 | GPR52 (0.78) | GPR52S1PR5S1PR4 | |
| SCHEMBL1853172 | 0.81 | GPR52 (0.67) | GPR52S1PR5S1PR4NR4A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |