Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | COMT | P21964 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20438285 | 0.79 | ALDH1A1 (0.38) | CARM1PRMT6KDM4EPIK3CDALDH1A1 | |
| SCHEMBL19026752 | 0.76 | — | — | |
| SCHEMBL23489743 | 0.74 | — | — | |
| SCHEMBL15200529 | 0.74 | — | — | |
| SCHEMBL30054804 | 0.73 | LMNA (0.42) | CYP1A2CYP2D6CYP3A4TSHRALDH1A1 | |
| SCHEMBL15199512 | 0.71 | ALDH1A1 (0.35) | CYP1A2CYP2D6KDM4EPIK3CDALDH1A1 | |
| SCHEMBL22760032 | 0.70 | IDO1 (0.33) | CARM1PRMT6CYP1A2CYP2D6KDM4E | |
| SCHEMBL29078411 | 0.70 | HTT (0.33) | CYP1A2CYP2D6TSHRPIK3CDNPC1 | |
| SCHEMBL10445655 | 0.69 | CYP1A2 (0.41) | CYP1A2CYP2D6KDM4ECYP3A4TSHR | |
| SCHEMBL2788882 | 0.68 | KDM4E (0.50) | KDM4ETSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999721-B2 | Pyrazole compounds and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2024-06-04 | — | — | US | disclosed |
| WO-2023143482-A1 | 2-AMINOPYRIMIDINE COMPOUND OR SALT, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海辉启生物医药科技有限公司 | 2023-08-03 | — | — | WO | disclosed |
| CN-110475771-B | CK1 and/or IRAK1 inhibitors, pharmaceutical compositions and therapeutic uses for cancer treatment | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-114127058-A | Heterocyclic compound, pharmaceutical composition and application thereof | 北京国鸿生物医药科技有限公司 | 2022-03-01 | — | — | CN | disclosed |
| US-20220017493-A1 | PYRAZOLE COMPOUNDS AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2022-01-20 | — | — | US | disclosed |
| US-20220017493-A1 | PYRAZOLE COMPOUNDS AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2022-01-20 | — | — | US | disclosed |
| WO-2021249417-A1 | HETEROCYCLIC COMPOUND AND DERIVATIVE THEREOF | 赛诺哈勃药业（成都）有限公司 | 2021-12-16 | — | — | WO | disclosed |
| EP-3577108-B1 | N1-(4-(5-(CYCLOPROPYLMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2-YL)CYCLOHEXANE-1,4-DIAMINE DERIVATIVES AND RELATED COMPOUNDS AS CK1 AND/OR IRAK1 INHIBITORS FOR TREATING CANCER | YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) | 2021-10-20 | — | — | EP | disclosed |
| EP-3577108-B1 | N1-(4-(5-(CYCLOPROPYLMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2-YL)CYCLOHEXANE-1,4-DIAMINE DERIVATIVES AND RELATED COMPOUNDS AS CK1 AND/OR IRAK1 INHIBITORS FOR TREATING CANCER | YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) | 2021-10-20 | — | — | EP | disclosed |
| EP-3331877-B1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL) | 2021-09-22 | — | — | EP | disclosed |
| US-20210251992-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2021-08-19 | — | — | US | disclosed |
| US-11072599-B2 | Pyrazole compounds and uses thereof | BIOTHERYX, INC. (US) | 2021-07-27 | — | — | US | disclosed |
| WO-2021143729-A1 | COMPOUND, COMPOSITION AND FUNCTIONAL MOLECULE WITH MULTI-TARGET INHIBITING EFFECT AND USE THEREOF | 中国科学院上海药物研究所 | 2021-07-22 | — | — | WO | disclosed |
| US-10960003-B2 | Pyrazole pyrimidine derivative and uses thereof | BIOTHERYX, INC. (US) | 2021-03-30 | — | — | US | disclosed |
| WO-2021000957-A1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 北京国鸿生物医药科技有限公司 | 2021-01-07 | — | — | WO | disclosed |
| US-20200354340-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2020-11-12 | — | — | US | disclosed |
| US-10376511-B2 | Pyrazole pyrimidine derivative and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2019-08-13 | — | — | US | disclosed |
| US-20180214447-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ISRAELI COMPANY, OF (IL) | 2018-08-02 | — | — | US | disclosed |
| US-20180214447-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ISRAELI COMPANY, OF (IL) | 2018-08-02 | — | — | US | disclosed |
| WO-2017021969-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2017-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999721-B2 | Pyrazole compounds and uses thereof | CYP11B2, CYP11B1, TPMT | CARM1 3006/4885PRMT6 1726/4885CYP1A2 14/4885 |
| US-10960003-B2 | Pyrazole pyrimidine derivative and uses thereof | IRAK1, IRAK2, IRAK3 | CARM1 1590/4885PRMT6 1699/4885CYP1A2 3462/4885 |
| US-20210251992-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | IRAK1, IRAK2, IRAK3 | CARM1 1590/4885PRMT6 1699/4885CYP1A2 3462/4885 |
| US-10376511-B2 | Pyrazole pyrimidine derivative and uses thereof | IRAK1, IRAK2, IRAK3 | CARM1 1590/4885PRMT6 1699/4885CYP1A2 3462/4885 |
| US-20220017493-A1 | PYRAZOLE COMPOUNDS AND USES THEREOF | CYP11B2, CYP11B1, TPMT | CARM1 3006/4885PRMT6 1726/4885CYP1A2 14/4885 |
| US-11072599-B2 | Pyrazole compounds and uses thereof | IRAK1, IRAK2, IRAK4 | CARM1 775/4885PRMT6 633/4885CYP1A2 2148/4885 |
| US-20200354340-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | IRAK1, IRAK2, IRAK4 | CARM1 982/4885PRMT6 683/4885CYP1A2 2301/4885 |
| US-20180214447-A1 | PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF | IRAK1, IRAK2, IRAK3 | CARM1 1590/4885PRMT6 1699/4885CYP1A2 3462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.