Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ADK | P55263 | 4/20 | 0.45 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11529405 | 0.89 | HIF1A (0.51) | HIF1APAX8ALDH1A1ADKDOT1L | |
| SCHEMBL18484348 | 0.86 | HIF1A (0.54) | HIF1APAX8ALDH1A1ADKDOT1L | |
| SCHEMBL22159896 | 0.86 | HIF1A (0.54) | HIF1APAX8ALDH1A1ADKDOT1L | |
| SCHEMBL18483493 | 0.85 | DOT1L (0.56) | HIF1APAX8ALDH1A1ADKDOT1L | |
| SCHEMBL18486808 | 0.85 | DOT1L (0.56) | HIF1APAX8ALDH1A1ADKDOT1L | |
| SCHEMBL18483520 | 0.85 | HIF1A (0.53) | HIF1APAX8ALDH1A1ADKDOT1L | |
| SCHEMBL7106108 | 0.84 | HIF1A (0.65) | HIF1APAX8ALDH1A1ADKDOT1L | |
| SCHEMBL7106111 | 0.84 | HIF1A (0.65) | HIF1APAX8ALDH1A1ADKDOT1L | |
| SCHEMBL18483661 | 0.84 | ADK (0.54) | HIF1AALDH1A1ADKADORA3ADORA1 | |
| SCHEMBL18483858 | 0.82 | ALDH1A1 (0.47) | HIF1APAX8ALDH1A1ADKADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002335-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2022-01-06 | — | — | US | disclosed |
| US-10941175-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2021-03-09 | — | — | US | disclosed |
| US-20200199167-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2020-06-25 | — | — | US | disclosed |
| US-10407457-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-20170253628-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-09-07 | — | — | US | disclosed |
| US-9708359-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-9701706-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20170137454-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-05-18 | — | — | US | disclosed |
| US-20170044202-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-02-16 | — | — | US | disclosed |
| WO-2017024310-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF USEFUL AS ANTIVIRAL AGENTS | CHIMERIX, INC. (US) | 2017-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407457-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | TYMP, PNP, DPYD | HIF1A 3466/4885PAX8 4156/4885ALDH1A1 776/4885 |
| US-20200199167-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, PNP, DPYD | HIF1A 3466/4885PAX8 4156/4885ALDH1A1 776/4885 |
| US-20220002335-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, PNP, DPYD | HIF1A 3466/4885PAX8 4156/4885ALDH1A1 776/4885 |
| US-20170137454-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, PNP, DPYD | HIF1A 3466/4885PAX8 4156/4885ALDH1A1 776/4885 |
| US-20170253628-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, PNP, DPYD | HIF1A 3466/4885PAX8 4156/4885ALDH1A1 776/4885 |
| US-20170044202-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, ITPA, IMPDH1 | HIF1A 3680/4885PAX8 3838/4885ALDH1A1 1417/4885 |
| US-10941175-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | TYMP, PNP, DPYD | HIF1A 3466/4885PAX8 4156/4885ALDH1A1 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.