Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 4/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1848299 | 0.90 | EP300 (0.47) | ROCK2HDAC1EP300MAPTCNR1 | |
| SCHEMBL1852052 | 0.86 | EP300 (0.39) | ROCK2HDAC1EPHX2EP300TACR1 | |
| SCHEMBL1850509 | 0.86 | HDAC1 (0.38) | ROCK2HDAC1EPHX2EP300TACR1 | |
| SCHEMBL1849353 | 0.86 | EP300 (0.36) | ROCK2HDAC1EPHX2EP300TACR1 | |
| SCHEMBL1847877 | 0.84 | EP300 (0.37) | ROCK2EPHX2EP300OPRM1 | |
| SCHEMBL1847919 | 0.84 | EP300 (0.37) | ROCK2HDAC1EPHX2EP300TACR1 | |
| SCHEMBL1848723 | 0.82 | EP300 (0.36) | ROCK2EPHX2EP300CNR1CNR2 | |
| SCHEMBL1848054 | 0.81 | PRKAB2 (0.38) | ROCK2HDAC1EPHX2EP300TACR1 | |
| SCHEMBL1127889 | 0.81 | CNR1 (0.40) | ROCK2HDAC1TACR1CNR1CNR2 | |
| SCHEMBL1847448 | 0.80 | LMNA (0.34) | ROCK2HDAC1EPHX2EP300TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324015-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010012964-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-02-04 | — | — | WO | disclosed |