Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1128119 | 0.82 | CNR1 (0.42) | CNR1CNR2 | |
| SCHEMBL1848627 | 0.81 | ROCK2 (0.38) | CNR1ROCK2HDAC1TACR1CNR2 | |
| SCHEMBL1127886 | 0.76 | CNR1 (0.55) | CNR1TACR1CNR2 | |
| SCHEMBL2570109 | 0.74 | ESR1 (0.51) | CNR1ESR1 | |
| SCHEMBL476187 | 0.73 | ROCK2 (0.37) | CNR1ROCK2HDAC1TACR1CNR2 | |
| SCHEMBL1848299 | 0.73 | EP300 (0.47) | CNR1ROCK2HDAC1 | |
| SCHEMBL1259435 | 0.71 | TACR1 (0.55) | CNR1TACR1CNR2 | |
| SCHEMBL1850509 | 0.71 | HDAC1 (0.38) | CNR1ROCK2HDAC1ESR1TACR1 | |
| SCHEMBL476315 | 0.71 | ROCK2 (0.35) | CNR1ROCK2HDAC1TACR1CNR2 | |
| SCHEMBL2569129 | 0.70 | CNR1 (0.38) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283008-A2 | PYRROLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC APPLICATION THEREOF | Sanofi-aventis (FR) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141533-A2 | PYRROLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2009-11-26 | — | — | WO | disclosed |