Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.35 |
| ▸ | FPR2 | P25090 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19913924 | 0.84 | KDM4E (0.42) | SYKKCNH2KMT2ALMNA | |
| SCHEMBL18488029 | 0.83 | SYK (0.36) | SYKKCNH2PIM1NNMTGRM2 | |
| SCHEMBL18449467 | 0.80 | PIM1 (0.34) | SYKKCNH2PIM1NNMTGRM2 | |
| SCHEMBL12569462 | 0.80 | PIM1 (0.39) | PIM1NNMTSCN9AFPR2KMT2A | |
| SCHEMBL19768940 | 0.79 | LMNA (0.41) | PIM1NNMTGRM2KMT2ALMNA | |
| SCHEMBL2827339 | 0.76 | TGFBR1 (0.42) | SYKKCNH2PIM1NNMTGRM2 | |
| SCHEMBL29502454 | 0.76 | TGFBR1 (0.42) | SYKKCNH2PIM1NNMTGRM2 | |
| SCHEMBL24959363 | 0.75 | APP (0.43) | PIM1NNMTGRM2SCN9AFPR2 | |
| SCHEMBL18451003 | 0.75 | TACR3 (0.35) | SYKKCNH2GRM2 | |
| SCHEMBL31228792 | 0.72 | PIM1 (0.41) | PIM1NNMTGRM2SCN9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023905-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ALPHA | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-02-09 | — | — | WO | disclosed |