Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18488361 | 0.85 | CYP2D6 (0.49) | TAAR1NPC1RAB9ASTK17ASTK17B | |
| SCHEMBL18488334 | 0.84 | GPR84 (0.42) | TAAR1KMT2AGPR84STK17ASTK17B | |
| SCHEMBL18488672 | 0.83 | MEN1 (0.50) | TAAR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL18488975 | 0.82 | PGK1 (0.48) | TAAR1NPC1RAB9AHIF1ALMNA | |
| SCHEMBL31044942 | 0.76 | NPC1 (0.45) | TAAR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL18487897 | 0.74 | CCND3 (0.41) | TAAR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL18493897 | 0.74 | STK17B (0.43) | TAAR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6267961 | 0.71 | HDAC3 (0.48) | TAAR1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL20421838 | 0.71 | CCND3 (0.53) | TAAR1HIF1ACCND3CDK6SRC | |
| SCHEMBL30395436 | 0.71 | CCND3 (0.53) | TAAR1HIF1ACCND3CDK6SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023899-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2017-02-09 | — | — | WO | disclosed |