SCHEMBL18489587

SCHEMBL18489587

COc1ccc2ccccc2c1C=Nc1c(C(C)C)cccc1C(C)C

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.58
HPGD P15428 1/20 0.58
ALDH1A1 P00352 5/20 0.45
CYP1A2 P05177 3/20 0.45
CYP2C19 P33261 3/20 0.45
CYP3A4 P08684 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
HIF1A Q16665 1/20 0.45
HSD17B10 Q99714 1/20 0.45
KMT2A Q03164 8/20 0.45
MEN1 O00255 7/20 0.45
GAA P10253 4/20 0.45
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
MAPT P10636 5/20 0.44
RECQL P46063 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CYP2C9 P11712 2/20 0.42
LMNA P02545 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18489585 1.00 KDM4E (0.58) KDM4EHPGDALDH1A1CYP1A2CYP2C19
SCHEMBL12379905 0.80 AMY1A (0.43) KDM4EALDH1A1CYP1A2KMT2AMEN1
SCHEMBL18489491 0.76 ALDH1A1 (0.47) ALDH1A1CYP1A2CYP2C19CYP3A4HIF1A
SCHEMBL18489492 0.76 ALDH1A1 (0.47) ALDH1A1CYP1A2CYP2C19CYP3A4HIF1A
SCHEMBL2314949 0.75 KDM4E (0.73) KDM4EHPGDALDH1A1CYP1A2CYP2C19
SCHEMBL10724211 0.74 KDM4E (1.00) KDM4EHPGDALDH1A1CYP1A2CYP2C19
SCHEMBL12787878 0.74 KDM4E (1.00) KDM4EHPGDALDH1A1CYP1A2CYP2C19
SCHEMBL6522025 0.74 KDM4E (1.00) KDM4EHPGDALDH1A1CYP1A2CYP2C19
SCHEMBL30933094 0.74 KMT2A (0.60) KDM4EHPGDALDH1A1CYP1A2CYP3A4
SCHEMBL9816957 0.73 KDM4E (0.97) KDM4EHPGDALDH1A1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3135699-B1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION, PREPARATION METHOD THEREFOR AND CATALYST HAVING SAME CHINA PETROLEUM & CHEM CORP (CN) 2021-07-21 EP claimed
US-10184017-B2 Catalyst component for propene polymerization, preparation method thereof, and catalyst containing the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2019-01-22 US claimed
EP-3135699-A1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION, PREPARATION METHOD THEREFOR AND CATALYST HAVING SAME China Petroleum & Chemical Corporation (CN) 2017-03-01 EP claimed
US-20170044280-A1 Catalyst Component for Propene Polymerization, Preparation Method Thereof, and Catalyst Containing the Same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2017-02-16 US claimed
EP-3135699-B1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION, PREPARATION METHOD THEREFOR AND CATALYST HAVING SAME CHINA PETROLEUM & CHEM CORP (CN) 2021-07-21 EP disclosed
US-10184017-B2 Catalyst component for propene polymerization, preparation method thereof, and catalyst containing the same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2019-01-22 US disclosed
EP-3135699-A1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION, PREPARATION METHOD THEREFOR AND CATALYST HAVING SAME China Petroleum & Chemical Corporation (CN) 2017-03-01 EP disclosed
US-20170044280-A1 Catalyst Component for Propene Polymerization, Preparation Method Thereof, and Catalyst Containing the Same CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2017-02-16 US disclosed