Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.36 |
| ▸ | BID | P55957 | 2/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31683730 | 0.85 | MEN1 (0.47) | IAPPEGFRERBB2HMGB1 | |
| SCHEMBL5182214 | 0.84 | TAAR1 (0.47) | IAPPALDH1A1LMNA | |
| SCHEMBL7804267 | 0.83 | IAPP (0.80) | IAPPBIDBCL2L1MCL1BAK1 | |
| SCHEMBL14793053 | 0.83 | ALOX5 (0.44) | IAPPALOX5PTGS2EGFRCA2 | |
| SCHEMBL18501453 | 0.81 | IAPP (0.57) | IAPPALOX5PTGS2CA2GABRA1 | |
| SCHEMBL11164405 | 0.79 | ALOX5 (0.57) | IAPPALOX5PTGS2EGFRGABRA1 | |
| SCHEMBL16051902 | 0.77 | ALOX5 (0.65) | IAPPALOX5PTGS2EGFRERBB2 | |
| SCHEMBL27522264 | 0.77 | FFAR1 (0.48) | IAPPEGFRCA2ACHEERBB2 | |
| SCHEMBL29086100 | 0.77 | IAPP (0.75) | IAPPBIDBCL2L1MCL1BAK1 | |
| SCHEMBL29086130 | 0.77 | IAPP (0.75) | IAPPBIDBCL2L1MCL1BAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037563-A1 | PROCESS FOR MAKING BERAPROST | UNITED THERAPEUTICS CORPORATION (US) | 2018-02-08 | — | — | US | disclosed |
| US-9765047-B2 | Process for making beraprost | UNITED THERAPEUTICS CORPORATION (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170044126-A1 | PROCESS FOR MAKING BERAPROST | UNITED THERAPEUTICS CORPORATION (US) | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037563-A1 | PROCESS FOR MAKING BERAPROST | DHPS, DDOST, COASY | IAPP 1937/4885ALOX5 490/4885PTGS2 497/4885 |
| US-20170044126-A1 | PROCESS FOR MAKING BERAPROST | DHPS, DDOST, COASY | IAPP 1937/4885ALOX5 490/4885PTGS2 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.