Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804267 | 0.84 | IAPP (0.80) | IAPP | |
| Acetone SCHEMBL27863904 | 0.83 | IAPP (0.50) | IAPPALDH1A1KDM4EHPGDHSD17B10 | |
| Acetic Acid SCHEMBL9466871 | 0.81 | BID (0.49) | IAPPALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL18501464 | 0.81 | IAPP (0.56) | IAPPALDH1A1GABRA1GABRB2LMNA | |
| SCHEMBL8400520 | 0.81 | ALDH1A1 (0.54) | IAPPALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9508631 | 0.81 | IAPP (0.42) | IAPPALDH1A1KDM4EHPGDHSD17B10 | |
| Acetic Acid SCHEMBL28009227 | 0.80 | BID (0.48) | IAPPALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL30697416 | 0.79 | FPR2 (0.50) | IAPPALDH1A1HPGDLMNAFPR2 | |
| SCHEMBL6580321 | 0.79 | NPSR1 (0.55) | IAPPALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL13595160 | 0.79 | FPR2 (0.50) | IAPPALDH1A1HPGDLMNAFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005753-B2 | Methods for producing beraprost and its derivatives | LUNG BIOTECHNOLOGY PBC (US) | 2018-06-26 | — | — | US | disclosed |
| US-20180037563-A1 | PROCESS FOR MAKING BERAPROST | UNITED THERAPEUTICS CORPORATION (US) | 2018-02-08 | — | — | US | disclosed |
| US-9765047-B2 | Process for making beraprost | UNITED THERAPEUTICS CORPORATION (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170166545-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | LUNG BIOTECHNOLOGY PBC (US) | 2017-06-15 | — | — | US | disclosed |
| US-20170044126-A1 | PROCESS FOR MAKING BERAPROST | UNITED THERAPEUTICS CORPORATION (US) | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166545-A1 | METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES | CYP51A1, COASY, BLVRB | IAPP 1086/4885ALDH1A1 832/4885KDM4E 3407/4885 |
| US-10005753-B2 | Methods for producing beraprost and its derivatives | CYP51A1, COASY, BLVRB | IAPP 1086/4885ALDH1A1 832/4885KDM4E 3407/4885 |
| US-20180037563-A1 | PROCESS FOR MAKING BERAPROST | DHPS, DDOST, COASY | IAPP 1937/4885ALDH1A1 808/4885KDM4E 1543/4885 |
| US-20170044126-A1 | PROCESS FOR MAKING BERAPROST | DHPS, DDOST, COASY | IAPP 1937/4885ALDH1A1 808/4885KDM4E 1543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.