Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 6/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17969217 | 0.85 | PDPK1 (0.74) | PDPK1NPC1RAB9ASMN1; SMN2GRM1 | |
| SCHEMBL4208195 | 0.85 | PDPK1 (0.74) | PDPK1NPC1RAB9ASMN1; SMN2GRM1 | |
| SCHEMBL4213637 | 0.84 | PDPK1 (0.72) | PDPK1NPC1RAB9ASMN1; SMN2PIM1 | |
| SCHEMBL4211027 | 0.83 | PDPK1 (0.71) | PDPK1NPC1RAB9ASMN1; SMN2GRM1 | |
| SCHEMBL4212378 | 0.83 | PDPK1 (0.71) | PDPK1NPC1RAB9ASMN1; SMN2PIM1 | |
| SCHEMBL4215734 | 0.80 | PKM (0.67) | PDPK1NPC1RAB9ASMN1; SMN2GRM1 | |
| SCHEMBL4213459 | 0.80 | PDPK1 (0.66) | PDPK1NPC1RAB9ASMN1; SMN2PIM1 | |
| SCHEMBL2368706 | 0.75 | RAB9A (0.97) | PDPK1NPC1RAB9ASMN1; SMN2CLK4 | |
| SCHEMBL2232829 | 0.73 | PDPK1 (0.66) | PDPK1NPC1RAB9APIM1PIM3 | |
| SCHEMBL4208731 | 0.73 | PDPK1 (0.56) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324006-B1 | Anti-cancer drugs and uses relating thereto for metastatic malignant melanoma and other cancers | KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LTD (IN) | 2014-08-13 | — | — | EP | disclosed |
| EP-2324006-A2 | ANTI-CANCER DRUGS AND USES RELATING THERETO FOR METASTATIC MALIGNANT MELANOMA AND OTHER CANCERS | Kasina Laila Innova Pharmaceuticals Private Ltd. (IN) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010029577-A2 | ANTI-CANCER DRUGS AND USES RELATING THERETO FOR METASTATIC MALIGNANT MELANOMA AND OTHER CANCERS | GOKARAJU GANGA RAJU (IN) | 2010-03-18 | — | — | WO | disclosed |
| EP-0882051-B1 | THIOPHENOPYRIMIDINES | JANSSEN PHARMACEUTICA NV (BE) | 2001-11-07 | — | — | EP | disclosed |