Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.72 |
| ▸ | DHPS | P49366 | 1/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850150 | 0.84 | PDPK1 (1.00) | PDPK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4212378 | 0.80 | PDPK1 (0.71) | PDPK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4211027 | 0.77 | PDPK1 (0.71) | PDPK1NPC1RAB9ASMN1; SMN2GSK3B | |
| SCHEMBL17969217 | 0.76 | PDPK1 (0.74) | PDPK1NPC1RAB9ASMN1; SMN2CYP17A1 | |
| SCHEMBL4208195 | 0.76 | PDPK1 (0.74) | PDPK1NPC1RAB9ASMN1; SMN2GSK3B | |
| SCHEMBL4213459 | 0.74 | PDPK1 (0.66) | PDPK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4215734 | 0.74 | PKM (0.67) | PDPK1NPC1RAB9ASMN1; SMN2PIK3CA | |
| SCHEMBL29723496 | 0.72 | LIMK1 (0.53) | DHPSGPR35CYP17A1CYP1A2GSK3B | |
| SCHEMBL4207689 | 0.71 | RAB9A (0.74) | PDPK1NPC1RAB9ASMN1; SMN2GSK3B | |
| SCHEMBL4208731 | 0.70 | PDPK1 (0.56) | PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030196-A1 | PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | claimed |
| US-20090030196-A1 | PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030196-A1 | PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS | PIM1, PIM3, PIM2 | PDPK1 13/4885DHPS 1759/4885GPR35 4757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.