Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.45 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853574 | 0.95 | GPR52 (0.48) | GPR52JMJD6KLKB1TP53GRM2 | |
| SCHEMBL1849622 | 0.90 | GPR52 (0.51) | GPR52JMJD6KLKB1TP53GRM2 | |
| SCHEMBL1857340 | 0.89 | GPR52 (0.46) | GPR52JMJD6KLKB1TP53GRM2 | |
| SCHEMBL1849364 | 0.86 | GPR52 (0.51) | GPR52JMJD6GRM2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3215484 | 0.85 | GPR52 (0.55) | GPR52JMJD6KLKB1TP53GRM2 | |
| SCHEMBL1852588 | 0.85 | GPR52 (0.53) | GPR52JMJD6KLKB1TP53ALDH1A1 | |
| SCHEMBL3217768 | 0.83 | GPR52 (0.50) | GPR52JMJD6KLKB1TP53GRM2 | |
| SCHEMBL1848441 | 0.83 | GPR52 (0.50) | GPR52SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1856096 | 0.83 | GPR52 (0.54) | GPR52JMJD6ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1851052 | 0.82 | GPR52 (0.58) | GPR52KLKB1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |