Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854994 | 0.96 | GPR52 (0.52) | GPR52TP53SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL1849622 | 0.95 | GPR52 (0.51) | GPR52TP53SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL1849364 | 0.91 | GPR52 (0.51) | GPR52SMN1; SMN2ALDH1A1ELANEGRM2 | |
| SCHEMBL1856096 | 0.90 | GPR52 (0.54) | GPR52SMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL1849196 | 0.90 | GPR52 (0.52) | GPR52SMN1; SMN2ALDH1A1GRM2JMJD6 | |
| SCHEMBL1853574 | 0.89 | GPR52 (0.48) | GPR52TP53SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL1851194 | 0.89 | GPR52 (0.70) | GPR52SMN1; SMN2ALDH1A1MAPTGRM2 | |
| SCHEMBL1852588 | 0.89 | GPR52 (0.53) | GPR52TP53SMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL1850607 | 0.88 | GPR52 (0.52) | GPR52TP53SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1851680 | 0.88 | GPR52 (0.51) | GPR52SMN1; SMN2NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041891-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041891-A1 | AMIDE COMPOUND | GPR52, GPR132, NR5A2 | GPR52 1/4885TP53 3403/4885SMN1; SMN2 4263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.