Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 5/20 | 0.58 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852544 | 0.91 | GPR52 (0.62) | GPR52KLKB1DGAT2ADORA3ADORA2B | |
| SCHEMBL1853932 | 0.90 | GPR52 (0.63) | GPR52KLKB1ADORA3ADORA2BSMN1; SMN2 | |
| SCHEMBL3209129 | 0.89 | GPR52 (0.69) | GPR52ADORA3ADORA2BAURKA | |
| SCHEMBL1853574 | 0.87 | GPR52 (0.48) | GPR52KLKB1SMN1; SMN2MAPT | |
| SCHEMBL1851055 | 0.86 | GPR52 (0.65) | GPR52ADORA3ADORA2B | |
| SCHEMBL3208468 | 0.86 | GPR52 (0.57) | GPR52KLKB1ADORA3ADORA2BAURKA | |
| SCHEMBL1849604 | 0.84 | GPR52 (0.81) | GPR52ADORA3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1848441 | 0.83 | GPR52 (0.50) | GPR52ADORA3ADORA2BSMN1; SMN2CYP2C9 | |
| SCHEMBL1850163 | 0.82 | GPR52 (0.45) | GPR52KLKB1SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL1850671 | 0.82 | GPR52 (0.62) | GPR52KLKB1DGAT2KMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |