Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18497220 | 0.88 | MEN1 (0.62) | MEN1KMT2AIDO1LMNAFGFR4 | |
| SCHEMBL18508428 | 0.85 | MEN1 (0.51) | MEN1KMT2ALMNAFGFR4MAPT | |
| SCHEMBL18508427 | 0.85 | MERTK (0.61) | MEN1KMT2AIDO1LMNAALDH1A1 | |
| SCHEMBL18497229 | 0.80 | TXNRD1 (0.52) | IDO1LMNAALDH1A1MAPTHTT | |
| SCHEMBL18508409 | 0.80 | IDO1 (0.47) | MEN1KMT2AIDO1LMNAALDH1A1 | |
| SCHEMBL31030224 | 0.78 | MERTK (0.48) | MEN1KMT2AALDH1A1FGFR4MAPT | |
| SCHEMBL18497230 | 0.77 | MEN1 (0.59) | MEN1KMT2ALMNAALDH1A1MAPT | |
| SCHEMBL18508426 | 0.75 | MEN1 (0.74) | MEN1KMT2AIDO1LMNAALDH1A1 | |
| SCHEMBL28054590 | 0.74 | MAPT (0.47) | MEN1KMT2AALDH1A1FGFR4MAPT | |
| SCHEMBL2272996 | 0.74 | MAPT (0.48) | MEN1KMT2AALDH1A1FGFR4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027359-A1 | PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-02-16 | — | — | WO | disclosed |